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| Verfasst von: | Ehrenreich, Hannelore [VerfasserIn]  |
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| | Nau, R. [VerfasserIn] |
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| | Dembowski, C. [VerfasserIn] |
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| | Hasselblatt, M. [VerfasserIn] |
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| | Barth, Martin [VerfasserIn] |
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| | Hahn, A. [VerfasserIn] |
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| | Schilling, Lothar [VerfasserIn] |
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| | Sirén, A. -L. [VerfasserIn] |
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| | Brück, W. [VerfasserIn] |
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| Titel: | Endothelin B receptor deficiency is associated with an increased rate of neuronal apoptosis in the dentate gyrus |
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| Verf.angabe: | H. Ehrenreich, R. Nau, C. Dembowski, M. Hasselblatt, M. Barth, A. Hahn, L. Schilling, A.-L. Sirén and W. Brück |
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| E-Jahr: | 1999 |
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| Jahr: | 28 December 1999 |
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| Umfang: | 9 S. |
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| Fussnoten: | Gesehen am 24.03.2022 |
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| Titel Quelle: | Enthalten in: Neuroscience |
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| Ort Quelle: | Amsterdam [u.a.] : Elsevier Science, 1976 |
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| Jahr Quelle: | 1999 |
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| Band/Heft Quelle: | 95(1999), 4, Seite 993-1001 |
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| ISSN Quelle: | 1873-7544 |
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| Abstract: | The dentate gyrus retains neuronal proliferative potential throughout life. Using immature endothelin B receptor-deficient (sl/sl) rats, a rabbit model of pneumococcal meningitis and autopsy brains from humans who died from pneumococcal meningitis, we explored the role of endothelin B receptors in physiological and pathological neuronal apoptosis in the dentate gyrus. At postnatal days 3-4, the rate of apoptosis in the dentate gyrus was high in all rats, declining to low levels in wild-type rats (+/+) on days 14 and 22, but remaining high in both homozygous (sl/sl) and heterozygous (sl/+) endothelin B receptor-deficient rats. Increased apoptosis was not significantly compensated for by neuronal proliferation. Hippocampal neuronal cultures also exhibited genotype-dependent apoptosis with the highest rate in neurons from homozygous endothelin B receptor-deficient (sl/sl) rats. In rabbit and human pneumococcal meningitis, increased apoptosis in the dentate gyrus was associated with loss of neuronal endothelin B receptor immunoreactivity. In conclusion, endothelin B receptors appear to act as neuronal survival factors in the dentate gyrus in rodents and man, both during postnatal development and under pathological conditions. |
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| DOI: | doi:10.1016/S0306-4522(99)00507-2 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1016/S0306-4522(99)00507-2 |
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| | Volltext: https://www.sciencedirect.com/science/article/pii/S0306452299005072 |
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| | DOI: https://doi.org/10.1016/S0306-4522(99)00507-2 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | apoptosis |
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| | dentate gyrus |
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| | endothelin |
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| | endothelin B receptors |
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| | proliferation |
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| K10plus-PPN: | 1796588512 |
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| Verknüpfungen: | → Zeitschrift |
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Endothelin B receptor deficiency is associated with an increased rate of neuronal apoptosis in the dentate gyrus / Ehrenreich, Hannelore [VerfasserIn]; 28 December 1999 (Online-Ressource)
