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| Verfasst von: | Stolp-Rastätter, Bettina [VerfasserIn]  |
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| | Stern, Marcel [VerfasserIn] |
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| | Ambiel, Ina [VerfasserIn] |
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| | Hofmann, Katharina [VerfasserIn] |
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| | Morath, Katharina [VerfasserIn] |
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| | Gallucci, Lara [VerfasserIn] |
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| | Cortese, Mirko [VerfasserIn] |
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| | Bartenschlager, Ralf [VerfasserIn] |
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| | Ruggieri, Alessia [VerfasserIn] |
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| | Graw, Frederik [VerfasserIn] |
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| | Rudelius, Martina [VerfasserIn] |
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| | Keppler, Oliver Till [VerfasserIn] |
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| | Fackler, Oliver Till [VerfasserIn] |
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| Titel: | SARS-CoV-2 variants of concern display enhanced intrinsic pathogenic properties and expanded organ tropism in mouse models |
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| Verf.angabe: | Bettina Stolp, Marcel Stern, Ina Ambiel, Katharina Hofmann, Katharina Morath, Lara Gallucci, Mirko Cortese, Ralf Bartenschlager, Alessia Ruggieri, Frederik Graw, Martina Rudelius, Oliver Till Keppler and Oliver Till Fackler |
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| E-Jahr: | 2022 |
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| Jahr: | February 15, 2022 |
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| Umfang: | 18 S. |
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| Fussnoten: | Gesehen am 28.03.2022 |
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| Titel Quelle: | Enthalten in: Cell reports |
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| Ort Quelle: | Maryland Heights, MO : Cell Press, 2012 |
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| Jahr Quelle: | 2022 |
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| Band/Heft Quelle: | 38(2022), 7, Artikel-ID 110387, Seite 1-13, e1-e5 |
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| ISSN Quelle: | 2211-1247 |
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| Abstract: | SARS-CoV-2 variants of concern (VOCs) display enhanced transmissibility and resistance to antibody neutralization. Comparing the early 2020 isolate EU-1 to the VOCs Alpha, Beta, and Gamma in mice transgenic for human ACE2 reveals that VOCs induce a broadened scope of symptoms, expand systemic infection to the gastrointestinal tract, elicit the depletion of natural killer cells, and trigger variant-specific cytokine production patterns. Gamma infections result in accelerated disease progression associated with increased immune activation and inflammation. All four SARS-CoV-2 variants induce pDC depletion in the lungs, paralleled by reduced interferon responses. Remarkably, VOCs also use the murine ACE2 receptor for infection to replicate in the lungs of wild-type animals, which induce cellular and innate immune responses that apparently curtail the spread of overt disease. VOCs thus display distinct intrinsic pathogenic properties with broadened tissue and host range. The enhanced pathogenicity of VOCs and their potential for reverse zoonotic transmission pose challenges to clinical and pandemic management. |
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| DOI: | doi:10.1016/j.celrep.2022.110387 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1016/j.celrep.2022.110387 |
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| | Volltext: https://www.sciencedirect.com/science/article/pii/S2211124722001085 |
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| | DOI: https://doi.org/10.1016/j.celrep.2022.110387 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Alpha variant |
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| | Beta variant |
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| | cellular immunity |
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| | cytokine production |
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| | Gamma variant |
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| | ISG expression |
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| | K18-hACE2 |
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| | SARS-CoV-2 |
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| | variants of concern |
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| K10plus-PPN: | 179680536X |
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| Verknüpfungen: | → Zeitschrift |
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SARS-CoV-2 variants of concern display enhanced intrinsic pathogenic properties and expanded organ tropism in mouse models / Stolp-Rastätter, Bettina [VerfasserIn]; February 15, 2022 (Online-Ressource)
