Navigation überspringen
Universitätsbibliothek Heidelberg
Status: Bibliographieeintrag

Verfügbarkeit
Standort: ---
Exemplare: ---
heiBIB
 Online-Ressource
Verfasst von:Bräutigam, Christa [VerfasserIn]   i
 Weykamp, C. [VerfasserIn]   i
 Hoffmann, Georg F. [VerfasserIn]   i
 Wevers, R. A. [VerfasserIn]   i
Titel:Neurotransmitter metabolites in CSF
Titelzusatz:an external quality control scheme
Verf.angabe:C. Bräutigam, C. Weykamp, G.F. Hoffmann, R.A. Wevers
E-Jahr:2002
Jahr:01 June 2002
Umfang:12 S.
Fussnoten:Gesehen am 30.03.2022
Titel Quelle:Enthalten in: Journal of inherited metabolic disease
Ort Quelle:Hoboken, NJ : Wiley, 1978
Jahr Quelle:2002
Band/Heft Quelle:25(2002), 4, Seite 287-298
ISSN Quelle:1573-2665
Abstract:We report an international external quality control scheme on neurotransmitter metabolites in cerebrospinal fluid (CSF). The neurotransmitter metabolites homovanillic acid (HVA), 5-hydroxyindoleacetic acid (5-HIAA) and 3-methoxy-4-hydroxyphenylglycol (MHPG) are analysed to diagnose inborn errors of neurotransmitter metabolism. HVA is the catabolite of dopamine; 5-HIAA is the catabolite of serotonin; and MHPG is the catabolite of noradrenaline. In the first phase, 12 laboratories from six countries participated in this special quality control scheme to define the present state of the art and achieve harmonization in analytical outcome and interpretation. In the second part, recoveries, dilutions and methods for sample preparation were compared. The results of 3 of 12 laboratories were excluded because of unacceptable intralaboratory coefficients of variations (CV) for HVA and/or 5-HIAA. The inter- and intralaboratory CVs, the linearity and the recovery were acceptable for the other laboratories for both parameters.Unacceptable differences in the reference ranges between laboratories, leading to differences in interpretation of the results, became obvious. There was a significant improvement of the interlaboratory CV for HVA after standardization with a calibrator. The reproducibility of MHPG measurement appeared to be adequately established in only two laboratories and recovery was low in all five measuring this metabolite. The quality control scheme is an invaluable tool for controlling the analytical outcome and providing support to laboratories to improve their quality.
DOI:doi:10.1023/A:1016550324235
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: https://doi.org/10.1023/A:1016550324235
 Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1023/A%3A1016550324235
 DOI: https://doi.org/10.1023/A:1016550324235
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1797043986
Verknüpfungen:→ Zeitschrift

Permanenter Link auf diesen Titel (bookmarkfähig):  https://katalog.ub.uni-heidelberg.de/titel/68901345   QR-Code
zum Seitenanfang