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Verfasst von:Göttig, Stephan [VerfasserIn]   i
 Möbest, Dietrich [VerfasserIn]   i
 Rüster, Brigitte [VerfasserIn]   i
 Grace, Bithiah [VerfasserIn]   i
 Winter, Sylvia [VerfasserIn]   i
 Seifried, Erhard [VerfasserIn]   i
 Gilles, Jens [VerfasserIn]   i
 Wieland, Thomas [VerfasserIn]   i
 Henschler, Reinhard [VerfasserIn]   i
Titel:Role of the monomeric GTPase Rho in hematopoietic progenitor cell migration and transplantation
Verf.angabe:Stephan Göttig, Dietrich Möbest, Brigitte Rüster, Bithiah Grace, Sylvia Winter, Erhard Seifried, Jens Gille, Thomas Wieland and Reinhard Henschler
Jahr:2006
Umfang:10 S.
Fussnoten:First published: 27 December 2005 ; Gesehen am 31.03.2022
Titel Quelle:Enthalten in: European journal of immunology
Ort Quelle:Weinheim : Wiley-VCH, 1971
Jahr Quelle:2006
Band/Heft Quelle:36(2006), 1, Seite 180-189
ISSN Quelle:1521-4141
Abstract:To investigate the role of the monomeric guanosine triphosphatase (GTPase) Rho on migration of hematopoietic progenitor cells (HPC), we employed different clostridial toxins which inhibit the Rho family of GTPases. Pretreatment with C2I-C3, a cell-accessible C3 transferase fusion protein that targets Rho, increased chemokinetic migration of the factor-dependent multipotent cell line Factor Dependent Cell Paterson with mixed lineage differentiation potential (FDCP-mix) and of primary lineage marker-depleted HPC in vitro. In contrast, treatment with lethal toxin (LT) from Clostridium sordellii, which predominantly inactivates Rac, and with toxin B from C. difficile, which inactivates Rho, Rac and Cdc42, decreased in vitro migration. When HPC pretreated with LT or toxin B were transplanted into mice, homing to the bone marrow was impaired, whereas C2I-C3 treatment did not alter HPC homing. However, in a competitive hematopoietic repopulation experiment in C57BL/6 mice, pretreatment of bone marrow cells with any of the inhibitors, including the Rho inhibitor C2I-C3, resulted in suppressed donor-type hematopoiesis. Our data indicate that whereas Rac supports HPC cell cycling, migration, short-term homing and hematopoietic regeneration, Rho coordinates down-regulation of HPC migration and is required for hematopoietic regeneration.
DOI:doi:10.1002/eji.200525607
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1002/eji.200525607
 DOI: https://doi.org/10.1002/eji.200525607
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:ADP Ribose Transferases
 Animals
 Botulinum Toxins
 Cell Line
 Cell Movement
 Enzyme Activation
 Enzyme Inhibitors
 Hematopoietic Stem Cell Transplantation
 Hematopoietic Stem Cells
 Mice
 rac GTP-Binding Proteins
 rho GTP-Binding Proteins
K10plus-PPN:1797137867
Verknüpfungen:→ Zeitschrift

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