| |  Online-Ressource |
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| Verfasst von: | Lutz, Susanne [VerfasserIn]  |
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| | Freichel-Blomquist, Andrea [VerfasserIn] |
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| | Yang, Yang [VerfasserIn] |
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| | Rümenapp, Ulrich [VerfasserIn] |
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| | Jakobs, Karl-Heinz [VerfasserIn] |
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| | Schmidt, Martina [VerfasserIn] |
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| | Wieland, Thomas [VerfasserIn] |
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| Titel: | The guanine nucleotide exchange factor p63RhoGEF, a specific link between Gq/11-coupled receptor signaling and RhoA |
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| Verf.angabe: | Susanne Lutz, Andrea Freichel-Blomquist, Yang Yang, Ulrich Rümenapp, Karl H. Jakobs, Martina Schmidt, Thomas Wieland |
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| E-Jahr: | 2005 |
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| Jahr: | 4 January 2005 |
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| Umfang: | 6 S. |
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| Fussnoten: | Im Titel ist "q/11" in Gq/11 tiefgestellt ; Gesehen am 01.04.2022 |
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| Titel Quelle: | Enthalten in: The journal of biological chemistry |
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| Ort Quelle: | Bethesda, Md. : ASBMB Publications, 1905 |
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| Jahr Quelle: | 2005 |
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| Band/Heft Quelle: | 280(2005), 12, Seite 11134-11139 |
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| ISSN Quelle: | 1083-351X |
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| Abstract: | The monomeric GTPase RhoA, which is a key regulator of numerous cellular processes, is activated by a variety of G protein-coupled receptors, through either G12 or G(q) family proteins. Here we report that p63RhoGEF, a recently identified RhoA-specific guanine nucleotide exchange factor, enhances the Rho-dependent gene transcription induced by agonist-stimulated G(q/11)-coupled receptors (M3-cholinoceptor, histamine H1 receptor) or GTPase-deficient mutants of G alpha(q) and G alpha11. We further demonstrate that active G alpha(q) or G alpha11, but not G alpha12 or G alpha13, strongly enhances p63RhoGEF-induced RhoA activation by direct protein-protein interaction with p63RhoGEF at its C-terminal half. Moreover, the activation of p63RhoGEF by G alpha(q/11) occurs independently of and in competition to the activation of the canonical G alpha(q/11) effector phospholipase C beta. Therefore, our results elucidate a new signaling pathway by which G alpha(q/11)-coupled receptors specifically induce Rho signaling through a direct interaction of activated G alpha(q/11) subunits with p63RhoGEF. |
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| DOI: | doi:10.1074/jbc.M411322200 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1074/jbc.M411322200 |
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| | DOI: https://doi.org/10.1074/jbc.M411322200 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Animals |
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| | Binding Sites |
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| | COS Cells |
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| | GTP-Binding Protein alpha Subunits, G12-G13 |
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| | GTP-Binding Protein alpha Subunits, Gq-G11 |
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| | Guanine Nucleotide Exchange Factors |
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| | Humans |
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| | Isoenzymes |
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| | Phospholipase C beta |
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| | Rho Guanine Nucleotide Exchange Factors |
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| | rhoA GTP-Binding Protein |
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| | Signal Transduction |
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| | Transcription, Genetic |
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| | Type C Phospholipases |
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| K10plus-PPN: | 1797318500 |
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| Verknüpfungen: | → Zeitschrift |
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¬The¬ guanine nucleotide exchange factor p63RhoGEF, a specific link between Gq/11-coupled receptor signaling and RhoA / Lutz, Susanne [VerfasserIn]; 4 January 2005 (Online-Ressource)
