| |  Online-Ressource |
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| Verfasst von: | Snabaitis, Andrew K. [VerfasserIn]  |
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| | Muntendorf, Andreas [VerfasserIn] |
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| | Wieland, Thomas [VerfasserIn] |
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| | Avkiran, Metin [VerfasserIn] |
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| Titel: | Regulation of the extracellular signal-regulated kinase pathway in adult myocardium |
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| Titelzusatz: | differential roles of Gq/11, Gi and G12/13 proteins in signalling by α1-adrenergic, endothelin-1 and thrombin-sensitive protease-activated receptors |
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| Verf.angabe: | Andrew K. Snabaitis, Andreas Muntendorf, Thomas Wieland, Metin Avkiran |
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| Jahr: | 2005 |
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| Umfang: | 10 S. |
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| Fussnoten: | Available online 6 November 2004 ; Gesehen am 01.04.2022 ; Im Titel sind "q/11" in Gq/11, "i" in Gi, "12/13" in G12/13 tiefgestellt |
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| Titel Quelle: | Enthalten in: Cellular signalling |
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| Ort Quelle: | Amsterdam [u.a.] : Elsevier Science, 1989 |
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| Jahr Quelle: | 2005 |
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| Band/Heft Quelle: | 17(2005), 5, Seite 655-664 |
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| ISSN Quelle: | 1873-3913 |
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| Abstract: | Using adenoviruses encoding RGS2, RGS4 and Lsc (regulator of G protein signalling (RGS) domain of p115 RhoGEF), we investigated the contributions of G(q/11), Gi and G(12/13) proteins to G protein-coupled receptor (GPCR)-mediated activation of the extracellular signal-regulated kinase (ERK) pathway in adult rat ventricular myocytes (ARVM). Exposure to phenylephrine, endothelin-1 (ET-1) or thrombin induced significant activation of ERK1/2 and their downstream target 90 kDa ribosomal S6 kinase (p90RSK), which was abolished by overexpression of RGS4 (inhibits signalling via G(q/11) and Gi) or RGS2 (inhibits signalling via G(q/11)). Pertussis toxin (inhibits signalling via Gi) only partially attenuated the activation of ERK1/2 and p90(RSK) by phenylephrine and ET-1, but abolished such activation by thrombin. Overexpression of Lsc (inhibits signalling via G(12/13)) did not affect the responses to phenylephrine and ET-1, but suppressed the activation of ERK1/2 and p90RSK by thrombin. We conclude that full activation of the ERK pathway in ARVM by alpha1-adrenergic, ET-1 and thrombin receptors requires the activation of distinct families of heterotrimeric G proteins. |
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| DOI: | doi:10.1016/j.cellsig.2004.10.008 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1016/j.cellsig.2004.10.008 |
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| | DOI: https://doi.org/10.1016/j.cellsig.2004.10.008 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Adenoviridae |
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| | Adrenergic alpha-1 Receptor Agonists |
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| | Adrenergic alpha-Agonists |
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| | Animals |
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| | Genetic Vectors |
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| | GTP-Binding Protein alpha Subunits |
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| | GTP-Binding Protein alpha Subunits, G12-G13 |
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| | GTP-Binding Protein alpha Subunits, Gi-Go |
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| | GTP-Binding Protein alpha Subunits, Gq-G11 |
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| | Guanine Nucleotide Exchange Factors |
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| | Male |
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| | MAP Kinase Signaling System |
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| | Myocytes, Cardiac |
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| | Pertussis Toxin |
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| | Phenylephrine |
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| | Protein Structure, Tertiary |
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| | Rats |
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| | Rats, Wistar |
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| | Receptor, Endothelin A |
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| | Receptors, Adrenergic, alpha-1 |
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| | Receptors, G-Protein-Coupled |
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| | Receptors, Thrombin |
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| | RGS Proteins |
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| | Rho Guanine Nucleotide Exchange Factors |
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| K10plus-PPN: | 1797323636 |
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| Verknüpfungen: | → Zeitschrift |
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Regulation of the extracellular signal-regulated kinase pathway in adult myocardium / Snabaitis, Andrew K. [VerfasserIn]; 2005 (Online-Ressource)
