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Verfasst von:Riedel, Frank [VerfasserIn]   i
 Philipp, Katrin [VerfasserIn]   i
 Sadick, Haneen [VerfasserIn]   i
 Gößler, Ulrich [VerfasserIn]   i
 Hörmann, Karl [VerfasserIn]   i
 Verse, Thomas [VerfasserIn]   i
Titel:Immunohistochemical analysis of radiation-induced non-healing dermal wounds of the head and neck
Verf.angabe:Frank Riedel, Katrin Philipp, Haneen Sadick, Ullrich Goessler, Karl Hörmann and Thomas Verse
E-Jahr:2005
Jahr:[March 2005]
Umfang:8 S.
Illustrationen:Illustrationen
Fussnoten:Gesehen am 01.04.2022
Titel Quelle:Enthalten in: In vivo
Ort Quelle:Kapandriti, Attiki : IIAR, 2004
Jahr Quelle:2005
Band/Heft Quelle:19(2005), 2 vom: März, Seite 343-350
ISSN Quelle:1791-7549
Abstract:Persistent, poorly healing wounds are a significant clinical problem in patients who have had previous irradiation. The pathology of chronic dermal ulcers is characterised by excessive proteolytic activity which degrades the extracellular matrix (required for cell migration) and growth factors and their receptors. Interestingly, the molecular basis of radiation-induced dermal wounds is poorly understood. The aim of this study was to investigate, by immunohistochemistry, the expression of the endothelial marker vWF, of angiogenic bFGF, VEGF and IL-8, of collagenases MMP-2 and MMP-9 and their inhibitors TIMP-1 and TIMP-2, in tissue samples from radiation-induced chronic dermal wounds and healthy control skin. Performing immunohistochemical detection of microvessels, an equivalent density of microvessels was observed within tissue samples from normal healthy skin and from radiation-induced non-healing cutaneous wounds. Investigation of angiogenic bFGF and VEGF demonstrated a decreased expression of both factors in the radiation-induced dermal wounds. The expression of angiogenic IL-8 was weak in both the healthy skin samples and the radiation-induced wounds. In addition, an increased expression of collagenases MMP-2 and MMP-9 protein within the radiation-induced wounds was demonstrated. While the expression of TIMP-1 showed no difference of expression between normal control skin and tissue samples from radiation-induced wounds, TIMP-2 expression was slightly increased compared to healthy controls. Our data suggest that radiation-induced dermal injuries often fail to heal because of decreased angiogenesis and persistently high concentrations of MMPs with an imbalance of their tissue inhibitors. The basic mechanisms of wound healing in radiation-induced dermal wounds at the molecular level need to be understood further for the development of innovative treatment strategies.
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Volltext: https://iv.iiarjournals.org/content/19/2/343
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:angiogenesis
 chronic wound
 MMP
 Radiation
 TIMP
K10plus-PPN:1797386484
Verknüpfungen:→ Zeitschrift

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