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Verfasst von:Götte, Karl [VerfasserIn]   i
 Tremmel, Susanne Carina [VerfasserIn]   i
 Popp, Susanne [VerfasserIn]   i
 Weber, Susanne [VerfasserIn]   i
 Hörmann, Karl [VerfasserIn]   i
 Bartram, Claus R. [VerfasserIn]   i
 Jauch, Anna [VerfasserIn]   i
Titel:Intratumoral genomic heterogeneity in advanced head and neck cancer detected by comparative genomic hybridization
Verf.angabe:Karl Götte, Susanne C. Tremmel, Susanne Popp, Susanne Weber, Karl Hörmann, Claus R. Bartram, Anna Jauch
E-Jahr:2005
Jahr:[2005]
Umfang:11 S.
Illustrationen:Diagramme
Fussnoten:Gesehen am 01.04.2022
Titel Quelle:Enthalten in: Current research in head and neck cancer
Ort Quelle:Basel : Karger, 2005
Jahr Quelle:2005
Band/Heft Quelle:(2005), Seite 38-48
ISBN Quelle:978-3-318-01119-7
Abstract:Objectives: Little is known about the extent of intratumoral genetic heterogeneity in head and neck squamous cell carcinoma (HNSCC). Material: Therefore, we examined 79 stage III and IV primary HNSCCs and matched lymph node metastases for over- and underrepresentation of specific chromosome regions by comparative genomic hybridization. Results: The overall ratio of gains and losses was higher in metastases (M) than in primary (P) tumors (4/1 vs. 2.5/1). Gains of 3q (78.1% P vs. 87.5% M) and 11q (78.1% P vs. 62.5% M), and deletions of 3p (43.8% P vs. 34.4% M) and 9p (31.3% P vs. 15.6% M) were most frequently detected. The highest rate of intratumoral discordance was observed for primary tumors and corresponding metastases (32.8%) compared to matched pairs of 2 metastases (26.5%), and of 2 anatomically distinct sides of 1 primary tumor (24.3%). Furthermore, the discordance rate was dependent on the primary tumor site (oral cavity 49.2%, oropharynx 31%, hypopharynx 30.3% and larynx 27.3%). In some tumors, the extent of genomic discordance argues against a monoclonal origin. Conclusion: We demonstrate a high individual variation of intratumoral genomic heterogeneity depending on the localization and selection of matched pairs. These findings are of specific importance in view of establishing prognostic markers.
DOI:doi:10.1159/000082462
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1159/000082462
 Volltext: https://www.karger.com/Article/FullText/82462
 DOI: https://doi.org/10.1159/000082462
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1797389270
Verknüpfungen:→ Sammelwerk

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