Status: Bibliographieeintrag
Standort: ---
Exemplare:
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| Online-Ressource |
Verfasst von: | Götte, Karl [VerfasserIn]  |
| Tremmel, Susanne Carina [VerfasserIn]  |
| Popp, Susanne [VerfasserIn]  |
| Weber, Susanne [VerfasserIn]  |
| Hörmann, Karl [VerfasserIn]  |
| Bartram, Claus R. [VerfasserIn]  |
| Jauch, Anna [VerfasserIn]  |
Titel: | Intratumoral genomic heterogeneity in advanced head and neck cancer detected by comparative genomic hybridization |
Verf.angabe: | Karl Götte, Susanne C. Tremmel, Susanne Popp, Susanne Weber, Karl Hörmann, Claus R. Bartram, Anna Jauch |
E-Jahr: | 2005 |
Jahr: | [2005] |
Umfang: | 11 S. |
Illustrationen: | Diagramme |
Fussnoten: | Gesehen am 01.04.2022 |
Titel Quelle: | Enthalten in: Current research in head and neck cancer |
Ort Quelle: | Basel : Karger, 2005 |
Jahr Quelle: | 2005 |
Band/Heft Quelle: | (2005), Seite 38-48 |
ISBN Quelle: | 978-3-318-01119-7 |
Abstract: | Objectives: Little is known about the extent of intratumoral genetic heterogeneity in head and neck squamous cell carcinoma (HNSCC). Material: Therefore, we examined 79 stage III and IV primary HNSCCs and matched lymph node metastases for over- and underrepresentation of specific chromosome regions by comparative genomic hybridization. Results: The overall ratio of gains and losses was higher in metastases (M) than in primary (P) tumors (4/1 vs. 2.5/1). Gains of 3q (78.1% P vs. 87.5% M) and 11q (78.1% P vs. 62.5% M), and deletions of 3p (43.8% P vs. 34.4% M) and 9p (31.3% P vs. 15.6% M) were most frequently detected. The highest rate of intratumoral discordance was observed for primary tumors and corresponding metastases (32.8%) compared to matched pairs of 2 metastases (26.5%), and of 2 anatomically distinct sides of 1 primary tumor (24.3%). Furthermore, the discordance rate was dependent on the primary tumor site (oral cavity 49.2%, oropharynx 31%, hypopharynx 30.3% and larynx 27.3%). In some tumors, the extent of genomic discordance argues against a monoclonal origin. Conclusion: We demonstrate a high individual variation of intratumoral genomic heterogeneity depending on the localization and selection of matched pairs. These findings are of specific importance in view of establishing prognostic markers. |
DOI: | doi:10.1159/000082462 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1159/000082462 |
| Volltext: https://www.karger.com/Article/FullText/82462 |
| DOI: https://doi.org/10.1159/000082462 |
Datenträger: | Online-Ressource |
Sprache: | eng |
K10plus-PPN: | 1797389270 |
Verknüpfungen: | → Sammelwerk |
Intratumoral genomic heterogeneity in advanced head and neck cancer detected by comparative genomic hybridization / Götte, Karl [VerfasserIn]; [2005] (Online-Ressource)
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