20 years of Hepcidin

• Verfasst von: Colucci, Silvia [VerfasserIn]
• Verfasst von: Marques, Oriana [VerfasserIn]
• Verfasst von: Altamura, Sandro [VerfasserIn]
• Titel: 20 years of Hepcidin
• Titelzusatz: how far we have come
• Verf.angabe: Silvia Colucci, Oriana Marques, Sandro Altamura
• E-Jahr: 2021
• Jahr: 12 June 2021
• Umfang: 13 S.
• Fussnoten: Gesehen am 01.04.2022
• Titel Quelle: Enthalten in: Seminars in hematology
• Ort Quelle: Philadelphia, Pa. : Saunders, 2000
• Jahr Quelle: 2021
• Band/Heft Quelle: 58(2021), 3, Seite 132-144
• ISSN Quelle: 1532-8686
• DOI: doi:10.1053/j.seminhematol.2021.05.001
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1797396498

Abstract

Twenty years ago the discovery of hepcidin deeply changed our understanding of the regulation of systemic iron homeostasis. It is now clear that hepcidin orchestrates systemic iron levels by controlling the amount of iron exported into the bloodstream through ferroportin. Hepcidin expression is increased in situations where systemic iron levels should be reduced, such as in iron overload and infection. Conversely, hepcidin is repressed during iron deficiency, hypoxia or expanded erythropoiesis, to increase systemic iron availability and sustain erythropoiesis. In this review, we will focus on molecular mechanisms of hepcidin regulation and on the pathological consequences of their disruption.