| |  Online-Ressource |
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| Verfasst von: | Henn, Dominic [VerfasserIn]  |
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| | Abu-Halima, Masood [VerfasserIn] |
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| | Kahraman, Mustafa [VerfasserIn] |
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| | Falkner, Florian [VerfasserIn] |
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| | Fischer, Katharina [VerfasserIn] |
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| | Barrera, Janos A. [VerfasserIn] |
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| | Chen, Kellen [VerfasserIn] |
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| | Gurtner, Geoffrey C. [VerfasserIn] |
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| | Keller, Andreas [VerfasserIn] |
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| | Kneser, Ulrich [VerfasserIn] |
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| | Meese, Eckart [VerfasserIn] |
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| | Schmidt, Volker-Jürgen [VerfasserIn] |
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| Titel: | A multivariable miRNA signature delineates the systemic hemodynamic impact of arteriovenous shunt placement in a pilot study |
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| Verf.angabe: | Dominic Henn, Masood Abu-Halima, Mustafa Kahraman, Florian Falkner, Katharina S. Fischer, Janos A. Barrera, Kellen Chen, Geoffrey C. Gurtner, Andreas Keller, Ulrich Kneser, Eckart Meese & Volker J. Schmidt |
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| E-Jahr: | 2020 |
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| Jahr: | 11 December 2020 |
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| Umfang: | 13 S. |
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| Fussnoten: | Gesehen am 02.04.2022 |
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| Titel Quelle: | Enthalten in: Scientific reports |
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| Ort Quelle: | [London] : Macmillan Publishers Limited, part of Springer Nature, 2011 |
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| Jahr Quelle: | 2020 |
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| Band/Heft Quelle: | 10(2020), Artikel-ID 21809, Seite 1-13 |
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| ISSN Quelle: | 2045-2322 |
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| Abstract: | Arteriovenous (AV) fistulas for hemodialysis can lead to cardiac volume loading and increased serum brain natriuretic peptide (BNP) levels. Whether short-term AV loop placement in patients undergoing microsurgery has an impact on cardiac biomarkers and circulating microRNAs (miRNAs), potentially indicating an increased hemodynamic risk, remains elusive. Fifteen patients underwent AV loop placement with delayed free flap anastomosis for microsurgical reconstructions of lower extremity soft-tissue defects. N-terminal pro-BNP (NT-proBNP), copeptin (CT-proAVP), and miRNA expression profiles were determined in the peripheral blood before and after AV loop placement. MiRNA expression in the blood was correlated with miRNA expression from AV loop vascular tissue. Serum NT-proBNP and copeptin levels exceeded the upper reference limit after AV loop placement, with an especially strong NT-proBNP increase in patients with preexistent cardiac diseases. A miRNA signature of 4 up-regulated (miR-3198, miR-3127-5p, miR-1305, miR-1288-3p) and 2 down-regulated miRNAs (miR30a-5p, miR-145-5p) which are related to cardiovascular physiology, showed a significant systemic deregulation in blood and venous tissue after AV loop placement. AV loop placement causes serum elevations of NT-proBNP, copeptin as well as specific circulating miRNAs, indicating a potentially increased hemodynamic risk for patients with cardiovascular comorbidities, if free flap anastomosis is delayed. |
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| DOI: | doi:10.1038/s41598-020-78905-y |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1038/s41598-020-78905-y |
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| | Volltext: https://www.nature.com/articles/s41598-020-78905-y |
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| | DOI: https://doi.org/10.1038/s41598-020-78905-y |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Cardiovascular diseases |
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| | Skin diseases |
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| | Trauma |
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| K10plus-PPN: | 1797404660 |
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| Verknüpfungen: | → Zeitschrift |
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¬A¬ multivariable miRNA signature delineates the systemic hemodynamic impact of arteriovenous shunt placement in a pilot study / Henn, Dominic [VerfasserIn]; 11 December 2020 (Online-Ressource)
