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Status: Bibliographieeintrag

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Verfasst von:Kofler, Othmar [VerfasserIn]   i
 Simbeck, Maximilian [VerfasserIn]   i
 Tomasi, Roland [VerfasserIn]   i
 Hinske, Ludwig Christian Giuseppe [VerfasserIn]   i
 Klotz, Laura Valentina [VerfasserIn]   i
 Uhle, Florian [VerfasserIn]   i
 Born, Frank [VerfasserIn]   i
 Pichlmaier, Maximilian [VerfasserIn]   i
 Hagl, Christian Matthias [VerfasserIn]   i
 Weigand, Markus A. [VerfasserIn]   i
 Zwißler, Bernhard [VerfasserIn]   i
 Dossow, Vera von [VerfasserIn]   i
Titel:Early use of methylene blue in vasoplegic syndrome
Titelzusatz:a 10-year propensity score matched cohort study
Verf.angabe:Othmar Kofler, Maximilian Simbeck, Roland Tomasi, Ludwig Christian Hinske, Laura Valentina Klotz, Florian Uhle, Frank Born, Maximilian Pichlmaier, Christian Hagl, Markus Alexander Weigand, Bernhard Zwißler and Vera von Dossow
E-Jahr:2022
Jahr:20 February 2022
Umfang:12 S.
Fussnoten:Gesehen am 04.04.2022
Titel Quelle:Enthalten in: Journal of Clinical Medicine
Ort Quelle:Basel : MDPI, 2012
Jahr Quelle:2022
Band/Heft Quelle:11(2022), 4, Artikel-ID 1121, Seite 1-12
ISSN Quelle:2077-0383
Abstract:Background: Vasoplegic syndrome is associated with increased morbidity and mortality in patients undergoing cardiac surgery. This retrospective, single-center study aimed to evaluate the effect of early use of methylene blue (MB) on hemodynamics after an intraoperative diagnosis of vasoplegic syndrome (VS). Methods: Over a 10-year period, all patients diagnosed with intraoperative VS (hypotension despite treatment with norepinephrine ≥0.3 μg/kg/min and vasopressin ≥1 IE/h) while undergoing heart surgery and cardiopulmonary bypass were identified, and their data were examined. The intervention group received MB (2 mg/kg intravenous) within 15 min after the diagnosis of vasoplegia, while the control group received standard therapy. The two groups were matched using propensity scores. Results: Of the 1022 patients identified with VS, 221 received MB intraoperatively, and among them, 60 patients received MB within 15 min after the diagnosis of VS. After early MB application, mean arterial pressure was significantly higher, and vasopressor support was significantly lower within the first hour (p = 0.015) after the diagnosis of vasoplegia, resulting in a lower cumulative amount of norepinephrine (p = 0.018) and vasopressin (p = 0.003). The intraoperative need of fresh frozen plasma in the intervention group was lower compared to the control group (p = 0.015). Additionally, the intervention group had higher creatinine values in the first three postoperative days (p = 0.036) without changes in dialysis incidence. The 90-day survival did not differ significantly (p = 0.270). Conclusion: Our results indicate the additive effects of MB use during VS compared to standard vasopressor therapy only. Early MB administration for VS may significantly improve the patients’ hemodynamics with minor side effects.
DOI:doi:10.3390/jcm11041121
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: https://doi.org/10.3390/jcm11041121
 Volltext: https://www.mdpi.com/2077-0383/11/4/1121
 DOI: https://doi.org/10.3390/jcm11041121
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:cardiac anesthesia
 cardiac surgery
 cardiopulmonary bypass
 methylene blue
 shock
 vasoplegia
 vasoplegic syndrome
 vasopressin
K10plus-PPN:1797412035
Verknüpfungen:→ Zeitschrift

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