| |  Online-Ressource |
|---|
| Verfasst von: | Plesca, Ioana [VerfasserIn]  |
|---|
| | Benešová, Iva [VerfasserIn] |
|---|
| | Beer, Carolin [VerfasserIn] |
|---|
| | Sommer, Ulrich [VerfasserIn] |
|---|
| | Müller, Luise [VerfasserIn] |
|---|
| | Wehner, Rebekka [VerfasserIn] |
|---|
| | Heiduk, Max [VerfasserIn] |
|---|
| | Aust, Daniela E. [VerfasserIn] |
|---|
| | Baretton, Gustavo Bruno [VerfasserIn] |
|---|
| | Bachmann, Michael [VerfasserIn] |
|---|
| | Feldmann, Anja [VerfasserIn] |
|---|
| | Weitz, Jürgen [VerfasserIn] |
|---|
| | Seifert, Lena [VerfasserIn] |
|---|
| | Seifert, Adrian [VerfasserIn] |
|---|
| | Schmitz, Marc [VerfasserIn] |
|---|
| Titel: | Clinical significance of tumor-infiltrating conventional and plasmacytoid dendritic cells in pancreatic ductal adenocarcinoma |
|---|
| Verf.angabe: | Ioana Plesca, Iva Benešová, Carolin Beer, Ulrich Sommer, Luise Müller, Rebekka Wehner, Max Heiduk, Daniela Aust, Gustavo Baretton, Michael P Bachmann, Anja Feldmann, Jürgen Weitz, Lena Seifert, Adrian M. Seifert and Marc Schmitz |
|---|
| E-Jahr: | 2022 |
|---|
| Jahr: | 26 February 2022 |
|---|
| Umfang: | 19 S. |
|---|
| Fussnoten: | Gesehen am 05.04.2022 |
|---|
| Titel Quelle: | Enthalten in: Cancers |
|---|
| Ort Quelle: | Basel : MDPI, 2009 |
|---|
| Jahr Quelle: | 2022 |
|---|
| Band/Heft Quelle: | 14(2022), 5, Artikel-ID 1216, Seite 1-19 |
|---|
| ISSN Quelle: | 2072-6694 |
|---|
| Abstract: | Dendritic cells (DCs) play a key role in the orchestration of antitumor immunity. Activated DCs efficiently enhance antitumor effects mediated by natural killer cells and T lymphocytes. Conversely, tolerogenic DCs essentially contribute to an immunosuppressive tumor microenvironment. Thus, DCs can profoundly influence tumor progression and clinical outcome of tumor patients. To gain novel insights into the role of human DCs in pancreatic ductal adenocarcinoma (PDAC), we explored the frequency, spatial organization, and clinical significance of conventional DCs type 1 (cDC1s) and type 2 (cDC2s) and plasmacytoid DCs (pDCs) in primary PDAC tissues. A higher density of whole tumor area (WTA)- and tumor stroma (TS)-infiltrating cDC1s was significantly associated with better disease-free survival (DFS). In addition, an increased frequency of intraepithelial tumor-infiltrating cDC2s was linked to better DFS and overall survival (OS). Furthermore, an increased density of WTA- and TS-infiltrating pDCs tended to improve DFS. Moreover, a higher frequency of WTA- and TS-infiltrating cDC1s and pDCs emerged as an independent prognostic factor for better DFS and OS. These findings indicate that tumor-infiltrating DCs can significantly influence the clinical outcome of PDAC patients and may contribute to the design of novel treatment options that target PDAC-infiltrating DCs. |
|---|
| DOI: | doi:10.3390/cancers14051216 |
|---|
| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext ; Verlag: https://doi.org/10.3390/cancers14051216 |
|---|
| | kostenfrei: Volltext: https://www.mdpi.com/2072-6694/14/5/1216 |
|---|
| | DOI: https://doi.org/10.3390/cancers14051216 |
|---|
| Datenträger: | Online-Ressource |
|---|
| Sprache: | eng |
|---|
| Sach-SW: | dendritic cells |
|---|
| | neoadjuvant chemotherapy |
|---|
| | pancreatic cancer |
|---|
| | tumor microenvironment |
|---|
| K10plus-PPN: | 1797605461 |
|---|
| Verknüpfungen: | → Zeitschrift |
|---|
Clinical significance of tumor-infiltrating conventional and plasmacytoid dendritic cells in pancreatic ductal adenocarcinoma / Plesca, Ioana [VerfasserIn]; 26 February 2022 (Online-Ressource)
