Prospective study of low-radiation and low-iodine dose aortic CT angiography in obese and non-obese patients

• Verfasst von: Fink, Matthias A. [VerfasserIn]
• Verfasst von: Hartmann, Sibylle [VerfasserIn]
• Verfasst von: Melzig, Claudius [VerfasserIn]
• Verfasst von: Steuwe, Andrea [VerfasserIn]
• Verfasst von: Partovi, Sasan [VerfasserIn]
• Verfasst von: Böckler, Dittmar [VerfasserIn]
• Verfasst von: Kauczor, Hans-Ulrich [VerfasserIn]
• Verfasst von: Rengier, Fabian [VerfasserIn]
• Titel: Prospective study of low-radiation and low-iodine dose aortic CT angiography in obese and non-obese patients
• Titelzusatz: image quality and impact of patient characteristics
• Verf.angabe: Matthias A. Fink, Sibylle Stoll, Claudius Melzig, Andrea Steuwe, Sasan Partovi, Dittmar Böckler, Hans-Ulrich Kauczor and Fabian Rengier
• E-Jahr: 2022
• Jahr: 10 March 2022
• Umfang: 13 S.
• Fussnoten: Gesehen am 05.04.2022
• Titel Quelle: Enthalten in: Diagnostics
• Ort Quelle: Basel : MDPI, 2011
• Jahr Quelle: 2022
• Band/Heft Quelle: 12(2022), 3, Artikel-ID 675, Seite 1-13
• ISSN Quelle: 2075-4418
• DOI: doi:10.3390/diagnostics12030675
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: aorta
• Sach-SW: computed tomography angiography
• Sach-SW: contrast media
• Sach-SW: obesity
• Sach-SW: radiation dosage
• K10plus-PPN: 1797633872
• K10plus-PPN:
  Universitätsbibliothek
• Lokale URL UB: Zum Volltext

Abstract

The purpose of this study was to prospectively analyse image quality and radiation dose of body mass index (BMI)-adapted low-radiation and low-iodine dose CTA of the thoracoabdominal aorta in obese and non-obese patients. This prospective, single-centre study included patients scheduled for aortic CTA between November 2017 and August 2020 without symptoms of high-grade heart failure. A BMI-adapted protocol was used: Group A/Group B, BMI < 30/≥ 30 kg/m2, tube potential 80/100 kVp, total iodine dose 14.5/17.4 g. Intraindividual comparison with the institutional clinical routine aortic CTA protocol was performed. The final study cohort comprised 161 patients (mean 71.1 ± 9.4 years, 32 women), thereof 126 patients in Group A (mean BMI 25.4 ± 2.8 kg/m2) and 35 patients in Group B (34.0 ± 3.4 kg/m2). Mean attenuation over five aortoiliac measurement positions for Group A/B was 354.9 ± 78.2/262.1 ± 73.0 HU. Mean effective dose for Group A/B was 3.05 ± 0.46/6.02 ± 1.14 mSv. Intraindividual comparison in 50 patients demonstrated effective dose savings for Group A/B of 34.4 ± 14.5/25.4 ± 14.1% (both p < 0.001), and iodine dose savings for Group A/B of 54/44.8%. Regression analysis showed that female sex and increasing age were independently associated with higher vascular attenuation. In conclusion, BMI-adapted, low-radiation and low-iodine dose CTA of the thoracoabdominal aorta delivers diagnostic image quality in non-obese and obese patients without symptoms of high-grade heart failure, with superior image quality in females and the elderly.