Status: Bibliographieeintrag
Standort: ---
Exemplare:
---
| |  Online-Ressource |
|---|
| Verfasst von: | Geginat, Gernot [VerfasserIn]  |
|---|
| | Kretschmar, Marianne [VerfasserIn] |
|---|
| | Walter, Simon [VerfasserIn] |
|---|
| | Junker, Dieter [VerfasserIn] |
|---|
| | Hof, Herbert [VerfasserIn] |
|---|
| | Nichterlein, Thomas [VerfasserIn] |
|---|
| Titel: | Suppression of acquired immunity against Listeria monocytogenes by amphotericin B$bmediated inhibition of CD8 T cell function |
|---|
| Verf.angabe: | Gernot Geginat, Marianne Kretschmar, Simon Walter, Dieter Junker, Herbert Hof, Thomas Nichterlein |
|---|
| E-Jahr: | 1999 |
|---|
| Jahr: | 8 September 1999 |
|---|
| Umfang: | 9 S. |
|---|
| Fussnoten: | Gesehen am 06.04.2022 |
|---|
| Titel Quelle: | Enthalten in: The journal of infectious diseases |
|---|
| Ort Quelle: | Oxford [u.a.] : Oxford Univ. Press, 1904 |
|---|
| Jahr Quelle: | 1999 |
|---|
| Band/Heft Quelle: | 180(1999), 4, Seite 1186-1194 |
|---|
| ISSN Quelle: | 1537-6613 |
|---|
| Abstract: | Amphotericin B is frequently used for the treatment of fungal infections of immunocompromised individuals. Whereas immunomodulatory side effects of this agent are known, the influence of amphotericin B was studied in the model of murine Listeria monocytogenes infection. Treatment of L. monocytogenes-immune mice with a nontoxic dose of amphotericin B (0.75 mg/kg) reduced antilisterial protection by 4-5 orders of magnitude, while it had no significant effect on natural immunity against L. monocytogenes in naive mice. Treatment of mice with amphotericin B also abolished the protection mediated by transfer of an L. monocytogenes-specific CD8 T cell line. Furthermore, in vitro analysis showed that amphotericin B impaired target cell lysis and interferon-γ production by peptide-specific CD8 T cell lines and antigen presentation by L. monocytogenes-infected macrophagelike cells. These data indicate that amphotericin B has a strong suppressive effect on the function of CD8 T cells in vitro and in vivo. |
|---|
| DOI: | doi:10.1086/315007 |
|---|
| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1086/315007 |
|---|
| | DOI: https://doi.org/10.1086/315007 |
|---|
| Datenträger: | Online-Ressource |
|---|
| Sprache: | eng |
|---|
| K10plus-PPN: | 1797736191 |
|---|
| Verknüpfungen: | → Zeitschrift |
|---|
Suppression of acquired immunity against Listeria monocytogenes by amphotericin B$bmediated inhibition of CD8 T cell function / Geginat, Gernot [VerfasserIn]; 8 September 1999 (Online-Ressource)
68904230
