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Verfasst von:Bölsterli, Bigna [VerfasserIn]   i
 Schmitt, Bernhard [VerfasserIn]   i
 Bast, Thomas [VerfasserIn]   i
 Critelli, Hanne [VerfasserIn]   i
 Heinzle, Jakob [VerfasserIn]   i
 Jenni, Oskar G. [VerfasserIn]   i
 Huber, Reto [VerfasserIn]   i
Titel:Impaired slow wave sleep downscaling in encephalopathy with status epilepticus during sleep (ESES)
Verf.angabe:Bigna K. Bölsterli, Bernhard Schmitt, Thomas Bast, Hanne Critelli, Jakob Heinzle, Oskar G. Jenni, Reto Huber
E-Jahr:2011
Jahr:26 March 2011
Umfang:9 S.
Fussnoten:Gesehen am 06.04.2022
Titel Quelle:Enthalten in: Clinical neurophysiology
Ort Quelle:Amsterdam [u.a.] : Elsevier Science, 1999
Jahr Quelle:2011
Band/Heft Quelle:122(2011), 9 vom: Sept., Seite 1779-1787
ISSN Quelle:1872-8952
Abstract:Objective - “Encephalopathy related to electrical status epilepticus during slow wave sleep” (ESES) is characterised by the electroencephalographic pattern of continuous spike waves during slow wave sleep (CSWS) and variable neuropsychological impairments. The synaptic homeostasis hypothesis predicts that the strength of synapses is decreased during sleep. The slope of slow waves during NREM sleep best reflects this “downscaling”. - Methods - In a retrospective case control study, we analysed the time course of the slope of EEG slow waves of nine patients with ESES. The patients showed continuous spike waves (>85%) associated with regression or stagnation of cognitive functions. The data of the patient group were compared to nine healthy age and gender matched controls. - Results - In control subjects we found the expected decrease of the slope of slow waves from the first to the last hour of sleep (17.2% decrease, p<0.001). In contrast, patients showed no significant change in slope across the night. - Conclusions - This finding may reflect a disruption of the downscaling process during sleep, which may contribute to the developmental regression in these children. - Significance - Thus, our findings contribute to the understanding of the pathomechanisms leading to the regression observed in children with ESES and support the view that the goal of the treatment in children with ESES should not only be to reduce seizures, but also to resolve the continuous spike wave activity.
DOI:doi:10.1016/j.clinph.2011.01.053
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: https://doi.org/10.1016/j.clinph.2011.01.053
 Volltext: https://www.sciencedirect.com/science/article/pii/S1388245711001738
 DOI: https://doi.org/10.1016/j.clinph.2011.01.053
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Continuous spikes and waves during slow wave sleep
 Electrical status epilepticus during sleep
 Epileptic encephalopathy
 Sleep homeostasis
 Slow waves
K10plus-PPN:179774948X
Verknüpfungen:→ Zeitschrift

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