Increased soluble VCAM-1 serum levels in preeclampsia are not correlated to urinary excretion or circadian blood pressure rhythm

• Verfasst von: Heyl, Wolfgang [VerfasserIn]
• Verfasst von: Heintz, B. [VerfasserIn]
• Verfasst von: Reister, F. [VerfasserIn]
• Verfasst von: Harwig, S. [VerfasserIn]
• Verfasst von: Witte, Klaus [VerfasserIn]
• Verfasst von: Lemmer, Björn [VerfasserIn]
• Verfasst von: Rath, W. [VerfasserIn]
• Titel: Increased soluble VCAM-1 serum levels in preeclampsia are not correlated to urinary excretion or circadian blood pressure rhythm
• Verf.angabe: W. Heyl, B. Heintz, F. Reister, S. Harwig, K. Witte, B. Lemmer and W. Rath
• E-Jahr: 2005
• Jahr: 1. Juni 2005
• Umfang: 5 S.
• Fussnoten: Gesehen am 07.04.2022
• Titel Quelle: Enthalten in: Journal of perinatal medicine
• Ort Quelle: Berlin [u.a.] : de Gruyter, 1973
• Jahr Quelle: 2005
• Band/Heft Quelle: 33(2005), 2, Seite 144-148
• ISSN Quelle: 1619-3997
• DOI: doi:10.1515/JPM.2005.027
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Adhesion molecules
• Sach-SW: blood pressure
• Sach-SW: circadian rhythm
• Sach-SW: preeclampsia
• K10plus-PPN: 1798094320

Abstract

Objective : Soluble vascular cell adhesion molecule-1 (VCAM-1) is known to be elevated in serum of patients with preeclampsia, but there are no data available on the significance of urinary VCAM-1 excretion in preeclampsia. The aim of our study was to uncover possible circadian rhythms of VCAM-1 plasma levels and urinary VCAM-1 excretion in uncomplicated and hypertensive pregnancies and to ascertain their relation to blood pressure. Study design : A total of 10 normotensive and 10 preeclamptic pregnant women were included in this study. Venous blood was collected hourly, and urine samples were taken every 2 h over a period of 24 h. VCAM-1 levels were determined by ELISA. We compared these results with the circadian blood pressure rhythm. Results : The median VCAM-1 plasma levels were significantly (P<0.01) increased in preeclamptic patients (851.5 ng/mL) in comparison to normotensive pregnant women (659.3 ng/mL) without any circadian rhythm being apparent; however, the urinary excretion of VCAM-1 showed a typical circadian rhythm, with a higher excretion rate during daytime. Conclusion : For the first time we have demonstrated that urinary VCAM-1 excretion in pregnancy shows a circadian rhythm without correlation to plasma levels or the circadian blood pressure rhythm. In contrast, VCAM-1 serum levels did not show a diurnal rhythm. We assume that VCAM-1 serum levels do not correlate with systemic blood pressure or urinary excretion.