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Status: Bibliographieeintrag

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Verfasst von:Regnery, Sebastian [VerfasserIn]   i
 Behl, Nicolas G. R. [VerfasserIn]   i
 Platt, Tanja [VerfasserIn]   i
 Weinfurtner, Nina [VerfasserIn]   i
 Windisch, Paul [VerfasserIn]   i
 Deike-Hofmann, Katerina [VerfasserIn]   i
 Sahm, Felix [VerfasserIn]   i
 Bendszus, Martin [VerfasserIn]   i
 Debus, Jürgen [VerfasserIn]   i
 Ladd, Mark E. [VerfasserIn]   i
 Schlemmer, Heinz-Peter [VerfasserIn]   i
 Rieken, Stefan [VerfasserIn]   i
 Adeberg, Sebastian [VerfasserIn]   i
 Paech, Daniel [VerfasserIn]   i
Titel:Ultra-high-field sodium MRI as biomarker for tumor extent, grade and IDH mutation status in glioma patients
Verf.angabe:Sebastian Regnery, Nicolas G.R. Behl, Tanja Platt, Nina Weinfurtner, Paul Windisch, Katerina Deike-Hofmann, Felix Sahm, Martin Bendszus, Jürgen Debus, Mark E. Ladd, Heinz-Peter Schlemmer, Stefan Rieken, Sebastian Adeberg, Daniel Paech
E-Jahr:2020
Jahr:12 September 2020
Umfang:7 S.
Fussnoten:Gesehen am 10.04.2022
Titel Quelle:Enthalten in: NeuroImage: Clinical
Ort Quelle:[Amsterdam u.a.] : Elsevier, 2012
Jahr Quelle:2020
Band/Heft Quelle:28(2020), Artikel-ID 102427, Seite 1-7
ISSN Quelle:2213-1582
Abstract:Purpose - This prospective clinical trial investigated sodium (23Na) MRI at 7 Tesla (T) field strength as biomarker for tumor extent, isocitrate dehydrogenase (IDH) mutation and O6-methylguanine DNA methyltransferase (MGMT) promotor methylation in glioma patients. - Methods - 28 glioma patients underwent 23Na MRI on a 7T scanner (Siemens Healthcare, Erlangen, Germany) parallel to standard 3T MRI before chemoradiation. Areas of Gadolinium-contrast enhancement (gdce), non-enhancing T2-hyperintensity (regarded as edema), necrosis, and normal-appearing white matter (nawm) were segmented on 3T MRI imaging and were co-registered with the 23Na images. The median total 23Na concentrations of all areas were compared by pairwise t-tests. Furthermore, areas of gdce and edema were merged to yield the whole tumor area without necrosis. Subsequently, the difference in median of the 23Na concentration of this whole tumor area was compared between IDH-mutated and IDH wild-type gliomas as well as MGMT methylated and MGMT not-methylated glioblastomas using Whitney-Mann U-tests. All p-values were corrected after the Bonferroni-Holm procedure. - Results - The 23Na concentration increased successively from nawm to necrotic areas (mean ± sd: nawm = 37.84 ± 5.87 mM, edema = 54.69 ± 10.64 mM, gdce = 61.72 ± 12.95 mM, necrosis = 81.88 ± 17.53 mM) and the concentrations differed statistically significantly between all regarded areas (adjusted p-values for all pairwise comparisons < 0.05). Furthermore, IDH-mutated gliomas showed significantly higher 23Na concentrations than IDH wild-type gliomas (median [interquartile range]: IDH wild-type = 52.37 mM [45.98 - 58.56 mM], IDH mutated = 65.02 mM [58.87-67.05 mM], p = 0.039). Among the glioblastomas, there was a trend towards increased 23Na concentration in MGMT methylated tumors that did not reach statistical significance (median [interquartile range]: MGMT methylated = 57.59 mM [50.70 - 59.17 mM], MGMT not methylated = 48.78 mM [45.88 - 53.91 mM], p = 1.0). - Conclusions - 23Na MRI correlates with the IDH mutation status and could therefore enhance image guidance towards biopsy sites as wells as image-guided surgery and radiotherapy. Furthermore, the successive decrease of 23Na concentration from central necrosis to normal-appearing white matter suggests a correlation with tumor infiltration.
DOI:doi:10.1016/j.nicl.2020.102427
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1016/j.nicl.2020.102427
 Volltext: https://www.sciencedirect.com/science/article/pii/S2213158220302643
 DOI: https://doi.org/10.1016/j.nicl.2020.102427
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Glioblastoma
 Glioma
 IDH mutation
 Non-invasive biomarker
 Sodium imaging
 Ultra-high-field MRI
K10plus-PPN:1798311755
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