Principles of translational science in medicine

• Titel: Principles of translational science in medicine
• Titelzusatz: from bench to bedside
• Mitwirkende: Wehling, Martin [HerausgeberIn]
• Verf.angabe: edited by Martin Wehling
• Ausgabe: 3rd ed.
• Verlagsort: San Diego
• Verlag: Elsevier Science & Technology
• Jahr: 2021
• Umfang: 1 online resource (495 pages)
• Fussnoten: Description based on publisher supplied metadata and other sources
• ISBN: 978-0-323-99962-5
• Datenträger: Online-Ressource
• Sprache: eng
• Bibliogr. Hinweis: Erscheint auch als : Druck-Ausgabe
• Sach-SW: Electronic books
• K10plus-PPN: 176436211X

Abstract

Front Cover -- Principles of Translational Science in Medicine -- Copyright Page -- Contents -- List of contributors -- I. Introduction -- 1 Introduction and definitions -- What is translational medicine? -- Primary translation versus secondary translation -- The history of translational medicine, obstacles, and remits -- References -- 2 Problems, challenges, and initiatives in translation -- Attrition -- What translational medicine can and cannot do -- The present status of translational medicine (initiatives and deficiencies) -- New pathways to discovery -- Research teams of the future -- Reengineering the clinical research enterprise -- Translational science in medicine: the current challenge -- References -- II. Target identification and validation -- 3 "Omics" translation: a challenge for laboratory medicine -- Introduction -- "Omics": what does it mean? -- Proteomics as a paradigm of problems in translational medicine -- Development of biomarkers: from discovery to clinical application -- Discovery -- Identification/characterization -- Validation -- Standardization/harmonization -- Clinical association and clinical benefit -- Translating omics into clinical practice -- Continuum of translation research and omics -- Conclusions -- References -- 4 The power of genomics, metabolomics, and other omics for target identification and validation -- Introduction -- Genomics -- Genomic tools -- Sequencing -- Sequencing by ligation -- Sequencing by synthesis -- Arrays -- Oligonucleotide microarrays -- cDNA microarrays -- Quantitative reverse transcription polymerase chain reaction and low-density arrays -- Applications of genomics in molecular medicine -- Molecular diagnostics -- Pharmacogenomics -- Metabolomics -- Metabolomics or metabonomics? -- Metabolite profiling -- Metabolite fingerprinting -- Metabolic footprinting.