Status: Bibliographieeintrag
Standort: ---
Exemplare:
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| Online-Ressource |
Titel: | Principles of translational science in medicine |
Titelzusatz: | from bench to bedside |
Mitwirkende: | Wehling, Martin [HerausgeberIn]  |
Verf.angabe: | edited by Martin Wehling |
Ausgabe: | 3rd ed. |
Verlagsort: | San Diego |
Verlag: | Elsevier Science & Technology |
Jahr: | 2021 |
Umfang: | 1 online resource (495 pages) |
Fussnoten: | Description based on publisher supplied metadata and other sources |
ISBN: | 978-0-323-99962-5 |
Abstract: | Front Cover -- Principles of Translational Science in Medicine -- Copyright Page -- Contents -- List of contributors -- I. Introduction -- 1 Introduction and definitions -- What is translational medicine? -- Primary translation versus secondary translation -- The history of translational medicine, obstacles, and remits -- References -- 2 Problems, challenges, and initiatives in translation -- Attrition -- What translational medicine can and cannot do -- The present status of translational medicine (initiatives and deficiencies) -- New pathways to discovery -- Research teams of the future -- Reengineering the clinical research enterprise -- Translational science in medicine: the current challenge -- References -- II. Target identification and validation -- 3 "Omics" translation: a challenge for laboratory medicine -- Introduction -- "Omics": what does it mean? -- Proteomics as a paradigm of problems in translational medicine -- Development of biomarkers: from discovery to clinical application -- Discovery -- Identification/characterization -- Validation -- Standardization/harmonization -- Clinical association and clinical benefit -- Translating omics into clinical practice -- Continuum of translation research and omics -- Conclusions -- References -- 4 The power of genomics, metabolomics, and other omics for target identification and validation -- Introduction -- Genomics -- Genomic tools -- Sequencing -- Sequencing by ligation -- Sequencing by synthesis -- Arrays -- Oligonucleotide microarrays -- cDNA microarrays -- Quantitative reverse transcription polymerase chain reaction and low-density arrays -- Applications of genomics in molecular medicine -- Molecular diagnostics -- Pharmacogenomics -- Metabolomics -- Metabolomics or metabonomics? -- Metabolite profiling -- Metabolite fingerprinting -- Metabolic footprinting. |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Aggregator: https://ebookcentral.proquest.com/lib/kxp/detail.action?docID=6679146 |
Datenträger: | Online-Ressource |
Sprache: | eng |
Bibliogr. Hinweis: | Erscheint auch als : Druck-Ausgabe |
Sach-SW: | Electronic books |
K10plus-PPN: | 176436211X |
978-0-323-99962-5
Principles of translational science in medicine / Wehling, Martin [HerausgeberIn]; 2021 (Online-Ressource)
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