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| Verfasst von: | Lengfelder, Eva [VerfasserIn]  |
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| | Reichert, A. [VerfasserIn] |
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| | Haferlach, Claudia [VerfasserIn] |
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| | Haase, D. [VerfasserIn] |
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| | Haferlach, T. [VerfasserIn] |
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| | Löffler, H. [VerfasserIn] |
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| | Staib, P. [VerfasserIn] |
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| | Heyll, A. [VerfasserIn] |
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| | Seifarth, Wolfgang [VerfasserIn] |
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| | Saußele, Susanne [VerfasserIn] |
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| | Fonatsch, C. [VerfasserIn] |
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| | Gassmann, Winfried [VerfasserIn] |
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| | Ludwig, Wolf-Dieter [VerfasserIn] |
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| | Hochhaus, Andreas [VerfasserIn] |
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| | Beelen, D. [VerfasserIn] |
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| | Aul, C. [VerfasserIn] |
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| | Sauerland, M.-C. [VerfasserIn] |
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| | Heinecke, A. [VerfasserIn] |
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| | Hehlmann, Rüdiger [VerfasserIn] |
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| | Wörmann, B. [VerfasserIn] |
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| | Hiddemann, W. [VerfasserIn] |
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| | Büchner, T. [VerfasserIn] |
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| Titel: | Double induction strategy including high dose cytarabine in combination with all-trans retinoic acid |
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| Titelzusatz: | effects in patients with newly diagnosed acute promyelocytic leukemia |
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| Verf.angabe: | E. Lengfelder, A. Reichert, C. Schoch, D. Haase, T. Haferlach, H. Löffler, P. Staib, A. Heyll, W. Seifarth, S. Saussele, C. Fonatsch, W. Gassmann, W.-D. Ludwig, A. Hochhaus, D. Beelen, C. Aul, M.-C. Sauerland, A. Heinecke, R. Hehlmann, B. Wörmann, W. Hiddemann, T. Büchner |
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| E-Jahr: | 2000 |
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| Jahr: | 04 August 2000 |
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| Umfang: | 9 S. |
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| Fussnoten: | Gesehen am 13.04.2022 |
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| Titel Quelle: | Enthalten in: Leukemia |
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| Ort Quelle: | London : Springer Nature, 1997 |
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| Jahr Quelle: | 2000 |
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| Band/Heft Quelle: | 14(2000), 8, Seite 1362-1370 |
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| ISSN Quelle: | 1476-5551 |
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| Abstract: | A prospective multicenter study was performed to investigate the clinical and molecular results of intensified double induction therapy including high-dose cytarabine (ara-C) in combination with ATRA in newly diagnosed acute promyelocytic leukemia (APL), followed by consolidation and 3 years maintenance therapy. Fifty-one patients, diagnosed and monitored from December 1994 to June 1999, were evaluated. The median age was 43 (16-60) years. The morphologic diagnosis was M3 in 40 (78%) and M3v in 11 (22%) patients. In 15 (30%) patients the initial white blood cell counts were ⩾5 × 109/l. The cytogenetic or molecular proof of the translocation t(15;17) was a mandatory prerequisite for eligibility. The diagnosis was confirmed by karyotyping in 46 and by RT-PCR of the PML/RARα transcript in 45 cases. The rate of complete hematological remission was 92% and the early death rate 8%. Monitoring of minimal residual disease by RT-PCR of PML/RARα (sensitivity 10−4) showed negativity in 29 of 32 (91%) evaluable cases after induction, in 23 of 25 (92%) after consolidation, and in 27 of 30 (90%) during maintenance, after a median time of 2, 4 and of 18 months after diagnosis, respectively. After a median follow-up of 27 months, the estimated actuarial 2 years overall and event-free survival were both 88% (79, 97), and the 2 years relapse-free survival 96% (90, 100). The high antileukemic efficacy of this treatment strategy is demonstrated by a rapid and extensive reduction of the malignant clone and by a low relapse rate. The results suggest that the intensity of the induction chemotherapy combined with ATRA is one of the factors which may have a critical influence on the outcome of APL. A randomized trial should assess the value of an induction therapy including ATRA and high-dose ara-C in comparison to standard-dose ara-C. |
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| DOI: | doi:10.1038/sj.leu.2401843 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1038/sj.leu.2401843 |
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| | Volltext: https://www.nature.com/articles/2401843 |
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| | DOI: https://doi.org/10.1038/sj.leu.2401843 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Cancer Research |
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| | general |
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| | Hematology |
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| | Intensive / Critical Care Medicine |
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| | Internal Medicine |
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| | Medicine/Public Health |
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| | Oncology |
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| K10plus-PPN: | 179951448X |
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| Verknüpfungen: | → Zeitschrift |
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Double induction strategy including high dose cytarabine in combination with all-trans retinoic acid / Lengfelder, Eva [VerfasserIn]; 04 August 2000 (Online-Ressource)
