| |  Online-Ressource |
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| Verfasst von: | Knoll, Maximilian [VerfasserIn]  |
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| | Waltenberger, Maria [VerfasserIn] |
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| | Furkel, Jennifer [VerfasserIn] |
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| | Wirkner, Ute [VerfasserIn] |
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| | Gahlawat, Aoife Ward [VerfasserIn] |
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| | Dokić, Ivana [VerfasserIn] |
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| | Schwager, Christian [VerfasserIn] |
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| | Adeberg, Sebastian [VerfasserIn] |
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| | Rieken, Stefan [VerfasserIn] |
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| | Keßler, Tobias [VerfasserIn] |
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| | Sahm, Felix [VerfasserIn] |
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| | König, Laila [VerfasserIn] |
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| | Herold-Mende, Christel [VerfasserIn] |
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| | Combs, Stephanie [VerfasserIn] |
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| | Debus, Jürgen [VerfasserIn] |
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| | Abdollahi, Amir [VerfasserIn] |
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| Titel: | Whole blood transcriptional fingerprints of high-grade glioma and longitudinal tumor evolution under carbon ion radiotherapy |
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| Verf.angabe: | Maximilian Knoll, Maria Waltenberger, Jennifer Furkel, Ute Wirkner, Aoife Ward Gahlawat, Ivana Dokic, Christian Schwager, Sebastian Adeberg, Stefan Rieken, Tobias Kessler, Felix Sahm, Laila König, Christel Herold-Mende, Stephanie E. Combs, Jürgen Debus and Amir Abdollahi |
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| E-Jahr: | 2022 |
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| Jahr: | 28 January 2022 |
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| Umfang: | 17 S. |
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| Fussnoten: | Gesehen am 13.04.2022 |
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| Titel Quelle: | Enthalten in: Cancers |
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| Ort Quelle: | Basel : MDPI, 2009 |
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| Jahr Quelle: | 2022 |
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| Band/Heft Quelle: | 14(2022), 3, Artikel-ID 684, Seite 1-17 |
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| ISSN Quelle: | 2072-6694 |
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| Abstract: | Purpose: To assess the value of whole blood transcriptome data from liquid biopsy (lbx) in recurrent high-grade glioma (rHGG) patients for longitudinal molecular monitoring of tumor evolution under carbon ion irradiation (CIR). Methods: Whole blood transcriptome (WBT) analysis (Illumina HumanHT-12 Expression BeadChips) was performed in 14 patients with rHGG pre re-irradiation (reRT) with CIR and 3, 6 and 9 weeks post-CIR (reRT grade III:5, 36%, IV:9, 64%). Patients were irradiated with 30, 33, 36 GyRBE (n = 5, 6, 3) in 3GyRBE per fraction. Results: WTB analysis showed stable correlation with treatment characteristics and patients tumor grade, indicating a preserved tumor origin specific as well as dynamic transcriptional fingerprints of peripheral blood cells. Initial histopathologic tumor grade was indirectly associated with TMEM173 (STING), DNA-repair (ATM, POLD4) and hypoxia related genes. DNA-repair, chromatin remodeling (LIG1, SMARCD1) and immune response (FLT3LG) pathways were affected post-CIR. Longitudinal WTB fingerprints identified two distinct trajectories of rHGG evolution, characterized by differential and prognostic CRISPLD2 expression pre-CIR. Conclusions: Lbx based WTB analysis holds the potential for molecular stratification of rHGG patients and therapy monitoring. We demonstrate the feasibility of the peripheral blood transcriptome as a sentinel organ for identification of patient, tumor characteristics and CIR specific fingerprints in rHGG. |
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| DOI: | doi:10.3390/cancers14030684 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.3390/cancers14030684 |
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| | Volltext: https://www.mdpi.com/2072-6694/14/3/684 |
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| | DOI: https://doi.org/10.3390/cancers14030684 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | biomarker |
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| | carbon ion irradiation |
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| | liquid biopsy |
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| | recurrent high-grade glioma |
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| | whole blood transcriptome |
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| K10plus-PPN: | 1799543498 |
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| Verknüpfungen: | → Zeitschrift |
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Whole blood transcriptional fingerprints of high-grade glioma and longitudinal tumor evolution under carbon ion radiotherapy / Knoll, Maximilian [VerfasserIn]; 28 January 2022 (Online-Ressource)
