Status: Bibliographieeintrag
Standort: ---
Exemplare:
---
| |  Online-Ressource |
|---|
| Verfasst von: | Jacke, Kerstin [VerfasserIn]  |
|---|
| | Witte, Klaus [VerfasserIn] |
|---|
| | Huser, Lutz [VerfasserIn] |
|---|
| | Behrends, Sönke [VerfasserIn] |
|---|
| | Lemmer, Björn [VerfasserIn] |
|---|
| Titel: | Contribution of the renin-angiotensin system to subsensitivity of soluble guanylyl cyclase in TGR(mREN2)27 rats |
|---|
| Verf.angabe: | Kerstin Jacke, Klaus Witte, Lutz Huser, Sönke Behrends, Björn Lemmer |
|---|
| E-Jahr: | 2000 |
|---|
| Jahr: | 28 August 2000 |
|---|
| Umfang: | 9 S. |
|---|
| Fussnoten: | Gesehen am 14.04.2022 |
|---|
| Titel Quelle: | Enthalten in: European journal of pharmacology |
|---|
| Ort Quelle: | New York, NY [u.a.] : Elsevier, 1967 |
|---|
| Jahr Quelle: | 2000 |
|---|
| Band/Heft Quelle: | 403(2000), 1/2, Seite 27-35 |
|---|
| ISSN Quelle: | 1879-0712 |
|---|
| Abstract: | Soluble guanylyl cyclase activity and its stimulation by diethylamineNONOate was measured in aortae from hypertensive TGR(mREN2)27 rats (TGR) and Sprague-Dawley controls. Superoxide dismutase was added in vitro to evaluate the contribution of oxidative breakdown of nitric oxide (NO) by superoxide anions. Expression of soluble guanylyl cyclase was assessed by reverse transcriptase-polymerase chain reaction (RT-PCR). Basal and stimulated soluble guanylyl cyclase activity was significantly reduced in TGR rats, addition of superoxide dismutase had no effect. Expression of soluble guanylyl cyclase subunits was not different between strains. The independent contribution of hypertension and the overactive renin-angiotensin system to soluble guanylyl cyclase subsensitivity was assessed after normalization of TGR's blood pressure by the Ca2+-channel blocker amlodipine or the angiotensin converting enzyme-inhibitor enalapril. Soluble guanylyl cyclase activity in TGR was slightly increased by amlodipine and almost completely restored by enalapril. In conclusion, TGR showed desensitized vascular soluble guanylyl cyclase, depending on their overactive renin-angiotensin system. |
|---|
| DOI: | doi:10.1016/S0014-2999(00)00577-X |
|---|
| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1016/S0014-2999(00)00577-X |
|---|
| | Volltext: https://www.sciencedirect.com/science/article/pii/S001429990000577X |
|---|
| | DOI: https://doi.org/10.1016/S0014-2999(00)00577-X |
|---|
| Datenträger: | Online-Ressource |
|---|
| Sprache: | eng |
|---|
| Sach-SW: | Aorta |
|---|
| | Guanylyl cyclase |
|---|
| | Hypertension |
|---|
| | Renin-angiotensin system |
|---|
| | Superoxide anion |
|---|
| K10plus-PPN: | 1799643883 |
|---|
| Verknüpfungen: | → Zeitschrift |
|---|
Contribution of the renin-angiotensin system to subsensitivity of soluble guanylyl cyclase in TGR(mREN2)27 rats / Jacke, Kerstin [VerfasserIn]; 28 August 2000 (Online-Ressource)
68907947
