| |  Online-Ressource |
|---|
| Verfasst von: | Xie, Rou-gang [VerfasserIn]  |
|---|
| | Chu, Wen-Guang [VerfasserIn] |
|---|
| | Liu, Da-Lu [VerfasserIn] |
|---|
| | Wang, Xu [VerfasserIn] |
|---|
| | Ma, Sui-Bin [VerfasserIn] |
|---|
| | Wang, Fei [VerfasserIn] |
|---|
| | Wang, Fu-Dong [VerfasserIn] |
|---|
| | Lin, Zhen [VerfasserIn] |
|---|
| | Wu, Wen-Bin [VerfasserIn] |
|---|
| | Lu, Na [VerfasserIn] |
|---|
| | Liu, Ying-Ying [VerfasserIn] |
|---|
| | Han, Wen-Juan [VerfasserIn] |
|---|
| | Zhang, Hui [VerfasserIn] |
|---|
| | Bai, Zhan-Tao [VerfasserIn] |
|---|
| | Hu, San-Jue [VerfasserIn] |
|---|
| | Tao, Hui-Ren [VerfasserIn] |
|---|
| | Kuner, Thomas [VerfasserIn] |
|---|
| | Zhang, Xu [VerfasserIn] |
|---|
| | Kuner, Rohini [VerfasserIn] |
|---|
| | Wu, Sheng-Xi [VerfasserIn] |
|---|
| | Luo, Ceng [VerfasserIn] |
|---|
| Titel: | Presynaptic NMDARs on spinal nociceptor terminals state-dependently modulate synaptic transmission and pain |
|---|
| Verf.angabe: | Rou-Gang Xie, Wen-Guang Chu, Da-Lu Liu, Xu Wang, Sui-Bin Ma, Fei Wang, Fu-Dong Wang, Zhen Lin, Wen-Bin Wu, Na Lu, Ying-Ying Liu, Wen-Juan Han, Hui Zhang, Zhan-Tao Bai, San-Jue Hu, Hui-Ren Tao, Thomas Kuner, Xu Zhang, Rohini Kuner, Sheng-Xi Wu & Ceng Luo |
|---|
| E-Jahr: | 2022 |
|---|
| Jahr: | 07 February 2022 |
|---|
| Umfang: | 23 S. |
|---|
| Fussnoten: | Gesehen am 21.04.2022 |
|---|
| Titel Quelle: | Enthalten in: Nature Communications |
|---|
| Ort Quelle: | [London] : Nature Publishing Group UK, 2010 |
|---|
| Jahr Quelle: | 2022 |
|---|
| Band/Heft Quelle: | 13(2022) vom: Feb., Artikel-ID 728, Seite 1-23 |
|---|
| ISSN Quelle: | 2041-1723 |
|---|
| Abstract: | Postsynaptic NMDARs at spinal synapses are required for postsynaptic long-term potentiation and chronic pain. However, how presynaptic NMDARs (PreNMDARs) in spinal nociceptor terminals control presynaptic plasticity and pain hypersensitivity has remained unclear. Here we report that PreNMDARs in spinal nociceptor terminals modulate synaptic transmission in a nociceptive tone-dependent manner. PreNMDARs depresses presynaptic transmission in basal state, while paradoxically causing presynaptic potentiation upon injury. This state-dependent modulation is dependent on Ca2+ influx via PreNMDARs. Small conductance Ca2+-activated K+ (SK) channels are responsible for PreNMDARs-mediated synaptic depression. Rather, tissue inflammation induces PreNMDARs-PKG-I-dependent BDNF secretion from spinal nociceptor terminals, leading to SK channels downregulation, which in turn converts presynaptic depression to potentiation. Our findings shed light on the state-dependent characteristics of PreNMDARs in spinal nociceptor terminals on modulating nociceptive transmission and revealed a mechanism underlying state-dependent transition. Moreover, we identify PreNMDARs in spinal nociceptor terminals as key constituents of activity-dependent pain sensitization. |
|---|
| DOI: | doi:10.1038/s41467-022-28429-y |
|---|
| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1038/s41467-022-28429-y |
|---|
| | Volltext: https://www.nature.com/articles/s41467-022-28429-y |
|---|
| | DOI: https://doi.org/10.1038/s41467-022-28429-y |
|---|
| Datenträger: | Online-Ressource |
|---|
| Sprache: | eng |
|---|
| Sach-SW: | Chronic pain |
|---|
| | Long-term potentiation |
|---|
| K10plus-PPN: | 1799953904 |
|---|
| Verknüpfungen: | → Zeitschrift |
|---|
Presynaptic NMDARs on spinal nociceptor terminals state-dependently modulate synaptic transmission and pain / Xie, Rou-gang [VerfasserIn]; 07 February 2022 (Online-Ressource)
