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Verfasst von:Niebergall-Roth, Elke [VerfasserIn]   i
 Singer, Manfred V. [VerfasserIn]   i
Titel:Control of pancreatic exocrine secretion via muscarinic receptors
Titelzusatz:which subtype(s) are involved?: a review
Verf.angabe:Elke Niebergall-Roth, Manfred V. Singer
Jahr:2003
Umfang:9 S.
Fussnoten:Available online 20 February 2012 ; Gesehen am 25.04.2022
Titel Quelle:Enthalten in: Pancreatology
Ort Quelle:Amsterdam : Elsevier, 2001
Jahr Quelle:2003
Band/Heft Quelle:3(2003), 4, Seite 284-292
ISSN Quelle:1424-3911
Abstract:The present report gives an overview of the experimental, pharmacological and molecular investigations that have been undertaken during the past two decades to characterize and identify the muscarinic receptor sub-type(s) involved in the cholinergic control of pancreatic exocrine secretion in humans and different animal species. The results published in the literature clearly indicate that both M1 and M3 receptors contribute to the regulation of pancreatic enzyme secretion, although contradictory conclusions have been drawn from secretory studies using specific M1 and M3 receptor antagonists in vivo and in vitro. Binding studies using specific M1 and M3 receptor antagonists have supported the existence of both M1 and M3 receptors on pancreatic acinar cells, which was confirmed by the demonstration of specific mRNA for both receptor subtypes in rat pancreatic acinar cells. In addition, experimental evidence exists that nonacinar (possibly presynaptic) M1 receptors also contribute to the control of pancreatic enzyme secretion. The role of the different muscarinic receptor subtypes in the control of pancreatic fluid and bicarbonate output, however, still needs to be clarified. Future research should cover the evaluation of the relative contribution of the different receptor subtypes to the regulation of pancreatic exocrine function, the localization of the receptors involved as well as possible species differences.
DOI:doi:10.1159/000071766
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1159/000071766
 Volltext: https://www.sciencedirect.com/science/article/pii/S1424390303800170
 DOI: https://doi.org/10.1159/000071766
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:4-DAMP
 Atropine
 M1 receptor
 M3 receptor
 Pancreatic exocrine secretion
 Pirenzepine
 Telenzepine
K10plus-PPN:1800106394
Verknüpfungen:→ Zeitschrift

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