Intratumoral genomic heterogeneity in advanced head and neck cancer detected by comparative genomic hybridization

• Verfasst von: Tremmel, Susanne Carina [VerfasserIn]
• Verfasst von: Götte, Karl [VerfasserIn]
• Verfasst von: Popp, Susanne [VerfasserIn]
• Verfasst von: Weber, Susanne [VerfasserIn]
• Verfasst von: Hörmann, Karl [VerfasserIn]
• Verfasst von: Bartram, Claus R. [VerfasserIn]
• Verfasst von: Jauch, Anna [VerfasserIn]
• Titel: Intratumoral genomic heterogeneity in advanced head and neck cancer detected by comparative genomic hybridization
• Verf.angabe: Susanne C. Tremmel, Karl Götte, Susanne Popp, Susanne Weber, Karl Hörmann, Claus R. Bartram, Anna Jauch
• E-Jahr: 2003
• Jahr: [15 July 2003]
• Umfang: 10 S.
• Illustrationen: 1 Diagramm
• Fussnoten: Gesehen am 27.04.2022
• Titel Quelle: Enthalten in: Cancer genetics and cytogenetics
• Ort Quelle: Amsterdam [u.a.] : Elsevier Science, 1979
• Jahr Quelle: 2003
• Band/Heft Quelle: 144(2003), 2 vom: Juli, Seite 165-174
• ISSN Quelle: 1873-4456
• DOI: doi:10.1016/S0165-4608(03)00011-6
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1800383185

Abstract

Little is known about the extent of intratumoral genetic heterogeneity in head and neck squamous cell carcinoma (HNSCC). We therefore examined 79 stage III and IV primary HNSCCs (P) and matched lymph node metastases (M) for over- and underrepresentation of specific chromosome regions by comparative genomic hybridization (CGH). The overall ratio of gains and losses was higher in metastases than in primary tumors (4/1 vs. 2.5/1). Gains of 3q (78.1% P vs. 87.5% M) and 11q (78.1% P vs. 62.5% M) and deletions of 3p (43.8% P vs. 34.4% M) and 9p (31.3% P vs. 15.6% M) were most frequently detected. The highest rate of intratumoral discordance was observed for primary tumors and corresponding metastases (32.8%) compared with matched pairs of two metastases (26.5%) and of two anatomically distinct sides of one primary tumor (24.3%). Furthermore, the discordance rate was dependent on the primary tumor site (oral cavity 49.2%, oropharynx 31%, hypopharynx 30.3%, and larynx 27.3%). In some tumors, the extent of genomic discordance argues against a monoclonal origin. In conclusion, we found a high individual variation of intratumoral genomic heterogeneity depending on the localization and selection of matched pairs. These findings are of specific importance in view of establishing prognostic markers.