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| Verfasst von: | Althaus, Karina [VerfasserIn]  |
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| | Möller, Peter [VerfasserIn] |
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| | Uzun, Günalp [VerfasserIn] |
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| | Singh, Anurag [VerfasserIn] |
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| | Beck, Annika [VerfasserIn] |
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| | Bettag, Martin [VerfasserIn] |
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| | Bösmüller, Hans [VerfasserIn] |
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| | Guthoff, Martina [VerfasserIn] |
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| | Dorn, Franziska [VerfasserIn] |
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| | Petzold, Gabor C. [VerfasserIn] |
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| | Henkes, Hans [VerfasserIn] |
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| | Heyne, Nils [VerfasserIn] |
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| | Jumaa, Hassan [VerfasserIn] |
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| | Kreiser, Kornelia [VerfasserIn] |
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| | Limpach, Caroline [VerfasserIn] |
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| | Luz, Beate [VerfasserIn] |
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| | Maschke, Matthias [VerfasserIn] |
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| | Müller, Janis A. [VerfasserIn] |
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| | Münch, Jan [VerfasserIn] |
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| | Nagel, Simon [VerfasserIn] |
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| | Pötzsch, Bernd [VerfasserIn] |
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| | Müller, Jens [VerfasserIn] |
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| | Schlegel, Christoph [VerfasserIn] |
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| | Viardot, Andreas [VerfasserIn] |
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| | Bäzner, Hansjörg [VerfasserIn] |
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| | Wolf, Marc [VerfasserIn] |
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| | Pelzl, Lisann [VerfasserIn] |
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| | Warm, Verena [VerfasserIn] |
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| | Willinek, Winfried A. [VerfasserIn] |
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| | Steiner, Jochen [VerfasserIn] |
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| | Schneiderhan-Marra, Nicole [VerfasserIn] |
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| | Vollherbst, Dominik [VerfasserIn] |
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| | Sachs, Ulrich J. [VerfasserIn] |
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| | Fend, Falko [VerfasserIn] |
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| | Bakchoul, Tamam [VerfasserIn] |
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| Titel: | Antibody-mediated procoagulant platelets in SARS-CoV-2- vaccination associated immune thrombotic thrombocytopenia |
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| Verf.angabe: | Karina Althaus, Peter Möller, Günalp Uzun, Anurag Singh, Annika Beck, Martin Bettag, Hans Bösmüller, Martina Guthoff, Franziska Dorn, Gabor C. Petzold, Hans Henkes, Nils Heyne, Hassan Jumaa, Kornelia Kreiser, Caroline Limpach, Beate Luz, Matthias Maschke, Janis A. Müller, Jan Münch, Simon Nagel, Bernd Pötzsch, Jens Müller, Christoph Schlegel, Andreas Viardot, Hansjörg Bäzner, Marc Wolf, Lisann Pelzl, Verena Warm, Winfried A. Willinek, Jochen Steiner, Nicole Schneiderhan-Marra, Dominik Vollherbst, Ulrich J. Sachs, Falko Fend, Tamam Bakchoul |
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| E-Jahr: | 2021 |
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| Jahr: | May 20, 2021 |
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| Umfang: | 10 S. |
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| Fussnoten: | Gesehen am 28.04.2022 |
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| Titel Quelle: | Enthalten in: Haematologica |
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| Ort Quelle: | Pavia : Ferrata Storti Foundation, 2014 |
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| Jahr Quelle: | 2021 |
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| Band/Heft Quelle: | 106(2021), 8p2170-2179 |
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| ISSN Quelle: | 1592-8721 |
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| Abstract: | The COVID-19 pandemic has resulted in significant morbidity and mortality worldwide. To prevent severe infection, mass COVID-19 vaccination campaigns with several vaccine types are currently underway. We report pathological and immunological findings in 8 patients who developed vaccine-induced immune thrombotic thrombocytopenia (VITT) after administration of SARS-CoV-2 vaccine ChAdOx1 nCoV-19. We analyzed patient material using enzyme immune assays, flow cytometry and heparin-induced platelet aggregation assay and performed autopsies on two fatal cases. Eight patients (5 female, 3 male) with a median age of 41.5 years (range, 24 to 53) were referred to us with suspected thrombotic complications 6 to 20 days after ChAdOx1 nCoV-19 vaccination. All patients had thrombocytopenia at admission. Patients had a median platelet count of 46.5 x109/L (range, 8 to 92). Three had a fatal outcome and 5 were successfully treated. Autopsies showed arterial and venous thromboses in various organs and the occlusion of glomerular capillaries by hyaline thrombi. Sera from VITT patients contain high titer antibodies against platelet factor 4 (PF4) (OD 2.59±0.64). PF4 antibodies in VITT patients induced significant increase in procoagulant markers (P-selectin and phosphatidylserine externalization) compared to healthy volunteers and healthy vaccinated volunteers. The generation of procoagulant platelets was PF4 and heparin dependent. We demonstrate the contribution of antibody-mediated platelet activation in the pathogenesis of VITT. |
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| DOI: | doi:10.3324/haematol.2021.279000 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.3324/haematol.2021.279000 |
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| | Volltext: https://haematologica.org/article/view/haematol.2021.279000 |
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| | DOI: https://doi.org/10.3324/haematol.2021.279000 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| K10plus-PPN: | 1800495617 |
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| Verknüpfungen: | → Zeitschrift |
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Antibody-mediated procoagulant platelets in SARS-CoV-2- vaccination associated immune thrombotic thrombocytopenia / Althaus, Karina [VerfasserIn]; May 20, 2021 (Online-Ressource)
