Central and peripheral neural control of pancreatic exocrine secretion

• Verfasst von: Niebergall-Roth, Elke [VerfasserIn]
• Verfasst von: Singer, Manfred V. [VerfasserIn]
• Titel: Central and peripheral neural control of pancreatic exocrine secretion
• Verf.angabe: E. Niebergall-Roth, M.V. Singer
• Jahr: 2001
• Umfang: 16 S.
• Fussnoten: Keine DOI vorhanden ; Gesehen am 02.05.2022
• Titel Quelle: Enthalten in: Journal of physiology and pharmacology
• Ort Quelle: Kraków : Institute of Physiology, Jagiellonian University School of Medicine, 2000
• Jahr Quelle: 2001
• Band/Heft Quelle: 52(2001), 4, Seite 523-538
• ISSN Quelle: 1899-1505
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Animals
• Sach-SW: Central Nervous System
• Sach-SW: Cholecystokinin
• Sach-SW: Gastrin-Releasing Peptide
• Sach-SW: Humans
• Sach-SW: Nitric Oxide
• Sach-SW: Pancreas
• Sach-SW: Peripheral Nervous System
• Sach-SW: Receptor, Muscarinic M1
• Sach-SW: Receptors, Muscarinic
• Sach-SW: Serotonin
• Sach-SW: Vagus Nerve
• K10plus-PPN: 1800619588

Abstract

Efferent vagal impulses act on the exocrine pancreas via pancreatic ganglia, where the impulses are modulated and modified, and terminate via postganglionic fibers at the acinar cells. Acinar muscarinic receptors of the subtype M1 play an important role for the mediation of the stimulatory vagal influences on pancreatic exocrine secretion. In dogs, a potentiative interaction exists between the two most important mediators of the pancreatic exocrine response to intraduodenal stimuli, efferent vagal impulses and CCK. In contrast to humans and rats, in which all action of CCK on pancreatic enzyme output is vagally mediated, CCK acts in dogs in part as a classical humoral factor independent of the cholinergic system. Although several peptides found in pancreatic nerve cell bodies or fibers can stimulate or inhibit pancreatic exocrine secretion, their physiological importance in the neural control of the exocrine pancreas needs to be further evaluated.