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| Verfasst von: | Fabarius, Alice [VerfasserIn]  |
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| | Leitner, Armin [VerfasserIn] |
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| | Hochhaus, Andreas [VerfasserIn] |
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| | Müller, Martin Christian [VerfasserIn] |
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| | Hanfstein, Benjamin [VerfasserIn] |
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| | Haferlach, Claudia [VerfasserIn] |
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| | Göhring, Gudrun [VerfasserIn] |
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| | Schlegelberger, Brigitte [VerfasserIn] |
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| | Jotterand, Martine [VerfasserIn] |
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| | Reiter, Andreas [VerfasserIn] |
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| | Jung-Munkwitz, Susanne [VerfasserIn] |
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| | Proetel, Ulrike [VerfasserIn] |
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| | Schwaab, Juliana [VerfasserIn] |
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| | Hofmann, Wolf-Karsten [VerfasserIn] |
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| | Schubert, Jörg [VerfasserIn] |
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| | Einsele, Hermann [VerfasserIn] |
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| | Ho, Anthony Dick [VerfasserIn] |
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| | Falge, Christiane [VerfasserIn] |
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| | Kanz, Lothar [VerfasserIn] |
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| | Neubauer, Andreas [VerfasserIn] |
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| | Kneba, Michael [VerfasserIn] |
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| | Stegelmann, Frank [VerfasserIn] |
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| | Pfreundschuh, Michael [VerfasserIn] |
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| | Waller, Cornelius F. [VerfasserIn] |
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| | Spiekermann, Karsten [VerfasserIn] |
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| | Baerlocher, Gabriela M. [VerfasserIn] |
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| | Lauseker, Michael [VerfasserIn] |
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| | Pfirrmann, Markus [VerfasserIn] |
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| | Hasford, Joerg [VerfasserIn] |
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| | Saußele, Susanne [VerfasserIn] |
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| | Hehlmann, Rüdiger [VerfasserIn] |
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| Titel: | Impact of additional cytogenetic aberrations at diagnosis on prognosis of CML |
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| Titelzusatz: | long-term observation of 1151 patients from the randomized CML Study IV |
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| Verf.angabe: | Alice Fabarius, Armin Leitner, Andreas Hochhaus, Martin C. Müller, Benjamin Hanfstein, Claudia Haferlach, Gudrun Göhring, Brigitte Schlegelberger, Martine Jotterand, Andreas Reiter, Susanne Jung-Munkwitz, Ulrike Proetel, Juliana Schwaab, Wolf-Karsten Hofmann, Jörg Schubert, Hermann Einsele, Anthony D. Ho, Christiane Falge, Lothar Kanz, Andreas Neubauer, Michael Kneba, Frank Stegelmann, Michael Pfreundschuh, Cornelius F. Waller, Karsten Spiekermann, Gabriela M. Baerlocher, Michael Lauseker, Markus Pfirrmann, Joerg Hasford, Susanne Saussele, and Rüdiger Hehlmann, for the Schweizerische Arbeitsgemeinschaft für Klinische Krebsforschung (SAKK) and the German CML Study Group |
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| E-Jahr: | 2011 |
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| Jahr: | December 22, 2011 |
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| Umfang: | 9 S. |
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| Fussnoten: | Gesehen am 02.05.2022 |
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| Titel Quelle: | Enthalten in: Blood |
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| Ort Quelle: | Washington, DC : American Society of Hematology, 1946 |
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| Jahr Quelle: | 2011 |
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| Band/Heft Quelle: | 118(2011), 26, Seite 6760-6768 |
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| ISSN Quelle: | 1528-0020 |
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| Abstract: | The prognostic relevance of additional cytogenetic findings at diagnosis of chronic myeloid leukemia (CML) is unclear. The impact of additional cytogenetic findings at diagnosis on time to complete cytogenetic (CCR) and major molecular remission (MMR) and progression-free (PFS) and overall survival (OS) was analyzed using data from 1151 Philadelphia chromosome-positive (Ph+) CML patients randomized to the German CML Study IV. At diagnosis, 1003 of 1151 patients (87%) had standard t(9;22)(q34;q11) only, 69 patients (6.0%) had variant t(v;22), and 79 (6.9%) additional cytogenetic aberrations (ACAs). Of these, 38 patients (3.3%) lacked the Y chromosome (−Y) and 41 patients (3.6%) had ACAs except −Y; 16 of these (1.4%) were major route (second Philadelphia [Ph] chromosome, trisomy 8, isochromosome 17q, or trisomy 19) and 25 minor route (all other) ACAs. After a median observation time of 5.3 years for patients with t(9;22), t(v;22), −Y, minor- and major-route ACAs, the 5-year PFS was 90%, 81%, 88%, 96%, and 50%, and the 5-year OS was 92%, 87%, 91%, 96%, and 53%, respectively. In patients with major-route ACAs, the times to CCR and MMR were longer and PFS and OS were shorter (P < .001) than in patients with standard t(9;22). We conclude that major-route ACAs at diagnosis are associated with a negative impact on survival and signify progression to the accelerated phase and blast crisis. |
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| DOI: | doi:10.1182/blood-2011-08-373902 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1182/blood-2011-08-373902 |
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| | DOI: https://doi.org/10.1182/blood-2011-08-373902 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| K10plus-PPN: | 1800637098 |
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| Verknüpfungen: | → Zeitschrift |
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Impact of additional cytogenetic aberrations at diagnosis on prognosis of CML / Fabarius, Alice [VerfasserIn]; December 22, 2011 (Online-Ressource)
