| |  Online-Ressource |
|---|
| Verfasst von: | Bazhin, Alexandr V. [VerfasserIn]  |
|---|
| | Ahn, Katharina von [VerfasserIn] |
|---|
| | Fritz, Jasmin [VerfasserIn] |
|---|
| | Bunge, Henriette [VerfasserIn] |
|---|
| | Maier, Caroline [VerfasserIn] |
|---|
| | Isayev, Orkhan [VerfasserIn] |
|---|
| | Neff, Florian Matthias [VerfasserIn] |
|---|
| | Siveke, Jens T. [VerfasserIn] |
|---|
| | Karakhanova, Svetlana [VerfasserIn] |
|---|
| Titel: | Pivotal antitumor role of the immune checkpoint molecule B7-H1 in pancreatic cancer |
|---|
| Verf.angabe: | Alexandr V. Bazhin, Katharina von Ahn, Jasmin Fritz, Henriette Bunge, Caroline Maier, Orkhan Isayev, Florian Neff, Jens T. Siveke & Svetlana Karakhanova |
|---|
| E-Jahr: | 2022 |
|---|
| Jahr: | 01 Mar 2022 |
|---|
| Umfang: | 14 S. |
|---|
| Fussnoten: | Gesehen am 02.05.2022 |
|---|
| Titel Quelle: | Enthalten in: OncoImmunology |
|---|
| Ort Quelle: | Abingdon : Taylor & Franics, 2012 |
|---|
| Jahr Quelle: | 2022 |
|---|
| Band/Heft Quelle: | 11(2022), 1, Artikel-ID e2043037, Seite 1-14 |
|---|
| ISSN Quelle: | 2162-402X |
|---|
| Abstract: | Immune checkpoint molecule B7-H1 plays a decisive immune regulatory role in different pathologies including cancer, and manipulation of B7-H1 expression became an attractive approach in cancer immunotherapy. Pancreatic cancer (PDAC) is characterized by pronounced immunosuppressive environment and B7-H1 expression correlates with PDAC prognosis. However, the first attempts to diminish B7-H1 expression in patients were not so successful. This points the complicity of PDAC immunosuppressive network and requires further examinations. We investigated the effect of B7-H1 deficiency in PDAC. Our results clearly show that partial or complete B7-H1 inhibition in vivo let to reduced tumor volume and improved survival of PDAC-bearing mice. This oncological benefit is due to the abrogation of immunosuppression provided by MDSC, macrophages, DC and Treg, which resulted in simultaneous restoration of anti-tumor immune response, namely improved accumulation and functionality of effector-memory CD4 and CD8 T cells. Our results underline the potential of B7-H1 molecule to control immunosuppressive network in PDAC and provide new issues for further clinical investigations. |
|---|
| DOI: | doi:10.1080/2162402X.2022.2043037 |
|---|
| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1080/2162402X.2022.2043037 |
|---|
| | DOI: https://doi.org/10.1080/2162402X.2022.2043037 |
|---|
| Datenträger: | Online-Ressource |
|---|
| Sprache: | eng |
|---|
| Sach-SW: | B7-H1 (PD-L1) |
|---|
| | B7-H1 knockout |
|---|
| | cancer immunotherapy |
|---|
| | immune checkpoint molecules |
|---|
| | immunosuppression |
|---|
| | pancreatic cancer |
|---|
| K10plus-PPN: | 1800646089 |
|---|
| Verknüpfungen: | → Zeitschrift |
|---|
Pivotal antitumor role of the immune checkpoint molecule B7-H1 in pancreatic cancer / Bazhin, Alexandr V. [VerfasserIn]; 01 Mar 2022 (Online-Ressource)
