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Verfasst von:Debette, Stéphanie [VerfasserIn]   i
 Metso, Tiina [VerfasserIn]   i
 Pezzini, Alessandro [VerfasserIn]   i
 Abboud, Shérine [VerfasserIn]   i
 Metso, Antti [VerfasserIn]   i
 Leys, Didier [VerfasserIn]   i
 Bersano, Anna [VerfasserIn]   i
 Louillet, Fabien [VerfasserIn]   i
 Caso, Valeria [VerfasserIn]   i
 Lamy, Chantal [VerfasserIn]   i
 Medeiros, Elisabeth [VerfasserIn]   i
 Samson, Yves [VerfasserIn]   i
 Grond-Ginsbach, Caspar [VerfasserIn]   i
 Engelter, Stefan T. [VerfasserIn]   i
 Thijs, Vincent [VerfasserIn]   i
 Beretta, Simone [VerfasserIn]   i
 Béjot, Yannick [VerfasserIn]   i
 Sessa, Maria [VerfasserIn]   i
 Lorenza Muiesan, Maria [VerfasserIn]   i
 Amouyel, Philippe [VerfasserIn]   i
 Castellano, Maurizio [VerfasserIn]   i
 Arveiler, Dominique [VerfasserIn]   i
 Tatlisumak, Turgut [VerfasserIn]   i
 Dallongeville, Jean [VerfasserIn]   i
Titel:Association of vascular risk factors with cervical artery dissection and ischemic stroke in young adults
Verf.angabe:Stéphanie Debette, Tiina Metso, Alessandro Pezzini, Shérine Abboud, Antti Metso, Didier Leys, Anna Bersano, Fabien Louillet, Valeria Caso, Chantal Lamy, Elisabeth Medeiros, Yves Samson, Caspar Grond-Ginsbach, Stefan T. Engelter, Vincent Thijs, Simone Beretta, Yannick Béjot, Maria Sessa, Maria Lorenza Muiesan, Philippe Amouyel, Maurizio Castellano, Dominique Arveiler, Turgut Tatlisumak, Jean Dallongeville; on behalf of the Cervical Artery Dissection and Ischemic Stroke Patients (CADISP) Group
E-Jahr:2011
Jahr:April 12, 2011
Umfang:8 S.
Fussnoten:Gesehen am 02.05.2022
Titel Quelle:Enthalten in: Circulation
Ort Quelle:Philadelphia, Pa. : Lippincott, Williams & Wilkins, 1950
Jahr Quelle:2011
Band/Heft Quelle:123(2011), 14, Seite 1537-1544
ISSN Quelle:1524-4539
Abstract:Background— - - Little is known about the risk factors for cervical artery dissection (CEAD), a major cause of ischemic stroke (IS) in young adults. Hypertension, diabetes mellitus, smoking, hypercholesterolemia, and obesity are important risk factors for IS. However, their specific role in CEAD is poorly investigated. Our aim was to compare the prevalence of vascular risk factors in CEAD patients versus referents and patients who suffered an IS of a cause other than CEAD (non-CEAD IS) in the multicenter Cervical Artery Dissection and Ischemic Stroke Patients (CADISP) study. - - Methods and Results— - - The study sample comprised 690 CEAD patients (mean age, 44.2±9.9 years; 43.9% women), 556 patients with a non-CEAD IS (44.7±10.5 years; 39.9% women), and 1170 referents (45.9±8.1 years; 44.1% women). We compared the prevalence of hypertension, diabetes mellitus, hypercholesterolemia, smoking, and obesity (body mass index ≥30 kg/m2) or overweightness (body mass index ≥25 kg/m2 and <30 kg/m2) between the 3 groups using a multinomial logistic regression adjusted for country of inclusion, age, and gender. Compared with referents, CEAD patients had a lower prevalence of hypercholesterolemia (odds ratio 0.55; 95% confidence interval, 0.42 to 0.71; P<0.0001), obesity (odds ratio 0.37; 95% confidence interval, 0.26 to 0.52; P<0.0001), and overweightness (odds ratio 0.70; 95% confidence interval, 0.57 to 0.88; P=0.002) but were more frequently hypertensive (odds ratio 1.67; 95% confidence interval, 1.32 to 2.1; P<0.0001). All vascular risk factors were less frequent in CEAD patients compared with young patients with a non-CEAD IS. The latter were more frequently hypertensive, diabetic, and current smokers compared with referents. - - Conclusion— - - These results, from the largest series to date, suggest that hypertension, although less prevalent than in patients with a non-CEAD IS, could be a risk factor of CEAD, whereas hypercholesterolemia, obesity, and overweightness are inversely associated with CEAD.
DOI:doi:10.1161/CIRCULATIONAHA.110.000125
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: https://doi.org/10.1161/CIRCULATIONAHA.110.000125
 Volltext: https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.110.000125
 DOI: https://doi.org/10.1161/CIRCULATIONAHA.110.000125
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:dissection
 hypercholesterolemia
 hypertension
 obesity
 stroke
K10plus-PPN:1800662084
Verknüpfungen:→ Zeitschrift

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