Daily honey consumption does not change CYP3A activity in humans

• Verfasst von: Rudofsky, Leonie [VerfasserIn]
• Verfasst von: Burhenne, Jürgen [VerfasserIn]
• Verfasst von: Weiß, Johanna [VerfasserIn]
• Verfasst von: Völker, Michael [VerfasserIn]
• Verfasst von: Unger, Matthias [VerfasserIn]
• Verfasst von: Mikus, Gerd [VerfasserIn]
• Verfasst von: Haefeli, Walter E. [VerfasserIn]
• Titel: Daily honey consumption does not change CYP3A activity in humans
• Verf.angabe: Leonie Fetzner, Jürgen Burhenne, PhD, Johanna Weiss, PhD, Michael Völker, Matthias Unger, PhD, Gerd Mikus, MD, and Walter Emil Haefeli, MD
• Jahr: 2011
• Umfang: 10 S.
• Fussnoten: Elektronische Reproduktion der Druckausgabe ; Gesehen am 05.05.2022
• Titel Quelle: Enthalten in: Journal of clinical pharmacology
• Ort Quelle: Hoboken, NJ : Wiley, 1961
• Jahr Quelle: 2011
• Band/Heft Quelle: 51(2011), 8, Seite 1223-1232
• ISSN Quelle: 1552-4604
• DOI: doi:10.1177/0091270010382022
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: CYP3A
• Sach-SW: food-drug interactions
• Sach-SW: Honey
• K10plus-PPN: 1801035253

Abstract

Several studies investigating the interaction of honey and drug-metabolizing enzymes showed controversial results, with some suggesting that honey induces CYP3A-mediated metabolism in mammals and humans. This clinical trial was conducted to determine the effect of repeated honey administration on human CYP3A enzyme activity using midazolam as a marker substance. In a randomized, single-blind, parallel-group study, 20 healthy volunteers were randomly assigned to receive either honey (2 × 20 g/d) or artificial honey (2 × 20 g/d) over a period of 10 days. To determine intestinal and hepatic CYP3A activity, oral (4 mg) and intravenous (2 mg) midazolam was administered in a semi-simultaneous way before honey administration, after the last honey administration, and 1 and 6 days thereafter. At baseline after oral midazolam, the partial metabolic clearance was similar in both groups (honey: 917.8 ± 234.6 mL/min vs artificial honey: 973.5 ± 373.8 mL/min). Ten days of honey administration did not change partial metabolic clearance (honey: 1016 ± 268 mL/min vs artificial honey: 1043 ± 450 mL/min), which was also true 1 and 6 days later. Neither honey nor artificial honey in amounts usually consumed affected the intestinal and hepatic CYP3A activity in healthy volunteers.