| |  Online-Ressource |
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| Verfasst von: | Huhle, Günter [VerfasserIn]  |
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| | Abletshauser, C. [VerfasserIn] |
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| | Mayer, Norman [VerfasserIn] |
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| | Weidinger, G [VerfasserIn] |
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| | Harenberg, Job [VerfasserIn] |
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| | Heene, Dieter L. [VerfasserIn] |
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| Titel: | Reduction of platelet activity markers in type II hypercholesterolemic patients by a HMG-CoA-reductase inhibitor |
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| Verf.angabe: | G. Huhle, C. Abletshauser, N. Mayer, G. Weidinger, J. Harenberg, D.L. Heene |
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| E-Jahr: | 1999 |
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| Jahr: | 20 September 1999 |
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| Umfang: | 6 S. |
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| Fussnoten: | Gesehen am 05.05.2022 |
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| Titel Quelle: | Enthalten in: Thrombosis research |
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| Ort Quelle: | Amsterdam [u.a.] : Elsevier Science, 1972 |
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| Jahr Quelle: | 1999 |
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| Band/Heft Quelle: | 95(1999), 5, Seite 229-234 |
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| ISSN Quelle: | 1879-2472 |
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| Abstract: | We have investigated the effects of a potent lipid-lowering therapy on the activity of platelets as measured ex vivo by the surface activation markers CD62 (PADGEM, P-selectin, GMP 140) and CD63 (GP53) in a double-blind, randomized, placebo-controlled study. Treatment with the HMG-CoA-reductase inhibitor fluvastatin (40 mg) significantly reduced the serum low density lipoprotein cholesterol concentration by 30% (p<0.01) and total cholesterol by 25% (p<0.01). The platelet membrane activation markers CD62 (PADGEM, P-selectin, GMP140) and 63 (GP53) significantly decreased by 22 and 13% (in terms of the relative fluorescence intensity) under the treatment with fluvastatin (p<0.05), respectively. The cholesterol-lowering effect is accompanied by a significant reduction of the platelet membrane activation markers CD62 and CD63 reflecting a reduced platelet activity that may contribute to the vasoprotective profile of fluvasatin. |
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| DOI: | doi:10.1016/S0049-3848(99)00037-7 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1016/S0049-3848(99)00037-7 |
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| | Volltext: https://www.sciencedirect.com/science/article/pii/S0049384899000377 |
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| | DOI: https://doi.org/10.1016/S0049-3848(99)00037-7 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Cholesterol |
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| | Flow cytometry |
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| | Hypercholesterolemia |
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| | Platelets |
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| | Statins |
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| K10plus-PPN: | 1801044694 |
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| Verknüpfungen: | → Zeitschrift |
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Reduction of platelet activity markers in type II hypercholesterolemic patients by a HMG-CoA-reductase inhibitor / Huhle, Günter [VerfasserIn]; 20 September 1999 (Online-Ressource)
