The role of T lymphocytes in ANCA associated vasculitis

• Verfasst von: Kälsch, Anna-Isabelle [VerfasserIn]
• Verfasst von: Woude, Fokko J. van der [VerfasserIn]
• Verfasst von: Yard, Benito A. [VerfasserIn]
• Titel: The role of T lymphocytes in ANCA associated vasculitis
• Titelzusatz: neglected or revisited?
• Verf.angabe: A.I. Kälsch, F.J. van der Woude, B.A. Yard
• Jahr: 2005
• Umfang: 4 S.
• Fussnoten: Gesehen am 05.05.2022
• Titel Quelle: Enthalten in: Clinical nephrology
• Ort Quelle: Deisenhofen, Munich : Dustri-Verl. Feistle, 2002
• Jahr Quelle: 2005
• Band/Heft Quelle: 64(2005), 6, Seite 471-474
• DOI: doi:10.5414/cnp64471
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Antibodies, Antineutrophil Cytoplasmic
• Sach-SW: Humans
• Sach-SW: T-Lymphocytes
• Sach-SW: Vasculitis
• K10plus-PPN: 1801050201

Abstract

"Antineutrophil cytoplasmic antibodies (ANCA) are pathogenic--Oh yes they are!" is the title of a recent review [Falk et al. 2002], discussing the current evidence on the pathogenic role of ANCA in vasculitis. But what about T lymphocytes? Do these cells also contribute to disease manifestation and if so to what extend? T-cells most likely play a role in delivering proper signals to autoreactive B cells for the production of ANCA, but, in the efferent arm of the immune response the involvement of T cells is less obvious and controversially discussed. Numerous studies provide evidence that peripheral T-cell phenotypes are dramatically changed in ANCA associated vasculitis (AAV) patients. How these changes relate to disease manifestation is still a matter of discussion. In an attempt to provide a better understanding of how T cells might play a role in AAV, the present paper will review recent data presented at the 12th international vasculitis and ANCA workshop.