| |  Online-Ressource |
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| Verfasst von: | Stroick, Mark Gregor [VerfasserIn]  |
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| | Alonso, Angelika [VerfasserIn] |
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| | Fatar, Marc [VerfasserIn] |
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| | Griebe, Martin [VerfasserIn] |
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| | Kreisel, Stefan H. [VerfasserIn] |
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| | Kern, Rolf [VerfasserIn] |
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| | Gaud, Emmanuel [VerfasserIn] |
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| | Arditi, Marcel [VerfasserIn] |
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| | Hennerici, Michael G. [VerfasserIn] |
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| | Meairs, Stephen [VerfasserIn] |
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| Titel: | Effects of simultaneous application of ultrasound and microbubbles on intracerebral hemorrhage in an animal model |
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| Verf.angabe: | Mark Stroick, Angelika Alonso, Marc Fatar, Martin Griebe, Stefan Kreisel, Rolf Kern, Emmanuel Gaud, Marcel Arditi, Michael Hennerici, Stephen Meairs |
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| E-Jahr: | 2006 |
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| Jahr: | 10 September 2006 |
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| Umfang: | 6 S. |
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| Fussnoten: | Gesehen am 06.05.2022 |
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| Titel Quelle: | Enthalten in: Ultrasound in medicine & biology |
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| Ort Quelle: | Amsterdam [u.a.] : Elsevier Science, 1973 |
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| Jahr Quelle: | 2006 |
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| Band/Heft Quelle: | 32(2006), 9, Seite 1377-1382 |
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| ISSN Quelle: | 1879-291X |
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| Abstract: | Microbubble-enhanced sonothrombolysis (MEST) may be an alternative therapeutic option in ischemic stroke. Clinical study of the efficacy of MEST as an adjunct stroke therapy, before imaging with CT or MRI, requires experimental data on the safety of this approach in the presence of hemorrhagic stroke. We, therefore, investigated the effect of diagnostic transcranial ultrasound combined with microbubbles (US + MB) in an experimental animal model of intracerebral hemorrhage (ICH). ICH was induced in anesthetized rats by intracerebral collagenase injection. Transcranial ultrasound (2 MHz, mechanical index 1.3, 1051 kPa) was applied 3 h after ICH induction to rat brains for 30 min during a continuous IV infusion of sulfur hexafluoride microbubbles (SonoVue). The size of cerebral hemorrhage, the extent of brain edema, and the amount of apoptosis were compared with those from control rats with ICH but without US + MB. Results showed no significant effect of US + MB on hemorrhage size (control 23.3 +/- 10.7 mm(3), US + MB 20.3 +/- 5.8 mm(3)), on the extent of brain edema (control 3.3 +/- 2.0%, US +MB 3.5 +/- 1.9%), or on the rate of apoptosis (control 5.2 +/- 1.5%, US + MB 5.2 +/- 1.0%). We conclude that diagnostic ultrasound in combination with microbubbles does not cause additional damage to the rat brain during ICH in our experimental set-up. This finding provides support for the use of MEST as an early stroke therapy. |
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| DOI: | doi:10.1016/j.ultrasmedbio.2006.05.027 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1016/j.ultrasmedbio.2006.05.027 |
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| | DOI: https://doi.org/10.1016/j.ultrasmedbio.2006.05.027 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Animals |
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| | Apoptosis |
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| | Brain Edema |
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| | Cerebral Hemorrhage |
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| | Contrast Media |
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| | Disease Models, Animal |
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| | Male |
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| | Microbubbles |
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| | Phospholipids |
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| | Rats |
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| | Rats, Wistar |
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| | Stroke |
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| | Sulfur Hexafluoride |
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| | Ultrasonic Therapy |
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| K10plus-PPN: | 1801092958 |
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| Verknüpfungen: | → Zeitschrift |
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Effects of simultaneous application of ultrasound and microbubbles on intracerebral hemorrhage in an animal model / Stroick, Mark Gregor [VerfasserIn]; 10 September 2006 (Online-Ressource)
