| |  Online-Ressource |
|---|
| Verfasst von: | Parigi, Sara M. [VerfasserIn]  |
|---|
| | Larsson, Ludvig [VerfasserIn] |
|---|
| | Das, Srustidhar [VerfasserIn] |
|---|
| | Ramirez Flores, Ricardo O. [VerfasserIn] |
|---|
| | Frede, Annika [VerfasserIn] |
|---|
| | Tripathi, Kumar P. [VerfasserIn] |
|---|
| | Diaz, Oscar E. [VerfasserIn] |
|---|
| | Selin, Katja [VerfasserIn] |
|---|
| | Morales, Rodrigo A. [VerfasserIn] |
|---|
| | Luo, Xinxin [VerfasserIn] |
|---|
| | Monasterio, Gustavo [VerfasserIn] |
|---|
| | Engblom, Camilla [VerfasserIn] |
|---|
| | Gagliani, Nicola [VerfasserIn] |
|---|
| | Sáez Rodríguez, Julio [VerfasserIn] |
|---|
| | Lundeberg, Joakim [VerfasserIn] |
|---|
| | Villablanca, Eduardo J. [VerfasserIn] |
|---|
| Titel: | The spatial transcriptomic landscape of the healing mouse intestine following damage |
|---|
| Verf.angabe: | Sara M. Parigi, Ludvig Larsson, Srustidhar Das, Ricardo O. Ramirez Flores, Annika Frede, Kumar P. Tripathi, Oscar E. Diaz, Katja Selin, Rodrigo A. Morales, Xinxin Luo, Gustavo Monasterio, Camilla Engblom, Nicola Gagliani, Julio Saez-Rodriguez, Joakim Lundeberg & Eduardo J. Villablanca |
|---|
| E-Jahr: | 2022 |
|---|
| Jahr: | 11 February 2022 |
|---|
| Umfang: | 16 S. |
|---|
| Fussnoten: | Gesehen am 06.05.2022 |
|---|
| Titel Quelle: | Enthalten in: Nature Communications |
|---|
| Ort Quelle: | [London] : Springer Nature, 2010 |
|---|
| Jahr Quelle: | 2022 |
|---|
| Band/Heft Quelle: | 13(2022), Artikel-ID 828, Seite 1-16 |
|---|
| ISSN Quelle: | 2041-1723 |
|---|
| Abstract: | The intestinal barrier is composed of a complex cell network defining highly compartmentalized and specialized structures. Here, we use spatial transcriptomics to define how the transcriptomic landscape is spatially organized in the steady state and healing murine colon. At steady state conditions, we demonstrate a previously unappreciated molecular regionalization of the colon, which dramatically changes during mucosal healing. Here, we identified spatially-organized transcriptional programs defining compartmentalized mucosal healing, and regions with dominant wired pathways. Furthermore, we showed that decreased p53 activation defined areas with increased presence of proliferating epithelial stem cells. Finally, we mapped transcriptomics modules associated with human diseases demonstrating the translational potential of our dataset. Overall, we provide a publicly available resource defining principles of transcriptomic regionalization of the colon during mucosal healing and a framework to develop and progress further hypotheses. |
|---|
| DOI: | doi:10.1038/s41467-022-28497-0 |
|---|
| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1038/s41467-022-28497-0 |
|---|
| | Volltext: https://www.nature.com/articles/s41467-022-28497-0 |
|---|
| | DOI: https://doi.org/10.1038/s41467-022-28497-0 |
|---|
| Datenträger: | Online-Ressource |
|---|
| Sprache: | eng |
|---|
| Sach-SW: | Data processing |
|---|
| | Gene expression analysis |
|---|
| | Inflammatory bowel disease |
|---|
| | Molecular medicine |
|---|
| K10plus-PPN: | 1801147221 |
|---|
| Verknüpfungen: | → Zeitschrift |
|---|
¬The¬ spatial transcriptomic landscape of the healing mouse intestine following damage / Parigi, Sara M. [VerfasserIn]; 11 February 2022 (Online-Ressource)
