| Online-Ressource |
Verfasst von: | Haas, Stephan [VerfasserIn]  |
| Andreas Koch, W [VerfasserIn]  |
| Schreiber, Stefan [VerfasserIn]  |
| Reinhard, Iris [VerfasserIn]  |
| Koyama, Noriko [VerfasserIn]  |
| Singer, Manfred V. [VerfasserIn]  |
| Böcker, Ulrich [VerfasserIn]  |
Titel: | -137 (G/C) IL-18 promoter polymorphism in patients with inflammatory bowel disease |
Verf.angabe: | Stephan L. Haas, W Andreas Koch, Stefan Schreiber, Iris Reinhard, Noriko Koyama, Manfred V. Singer & Ulrich Böcker |
Jahr: | 2005 |
Umfang: | 6 S. |
Fussnoten: | Published online: 08 Jul 2009 ; Gesehen am 09.05.2022 |
Titel Quelle: | Enthalten in: Scandinavian journal of gastroenterology |
Ort Quelle: | Abingdon : Taylor & Francis Group, 1966 |
Jahr Quelle: | 2005 |
Band/Heft Quelle: | 40(2005), 12, Seite 1438-1443 |
ISSN Quelle: | 1502-7708 |
Abstract: | Objective. There is strong evidence that genetic factors contribute to the susceptibility for inflammatory bowel diseases (IBD). Recently, IL-18 promoter polymorphisms were characterized as risk factors for inflammatory diseases such as sepsis, asthma and adult-onset Still's disease. The aim of this study was to determine whether the −137 (G/C) IL-18 promoter polymorphism was associated with IBD susceptibility. Material and methods. For association analysis, 470 patients with Crohn's disease (CD), 235 unrelated patients with ulcerative colitis (UC) and 347 controls were enrolled. Furthermore, 233 UC and 470 CD trios were included for segregation analysis. Genotyping was performed by application of the TaqMan MGB biallelic discrimination system. Results. When comparing genotype frequencies of CD and UC patients versus controls, no significant difference was found (p=0.089 and p=0.078, respectively). However, the Cochran-Armitage trend test revealed a rising probability for CD and UC with increasing number of G alleles (p=0.030 and 0.028, respectively) for the case-control analysis. On the contrary, the family-based transmission disequilibrium test (TDT) did not show an association of the G allele with CD or UC in 470 CD and 233 UC trios (p=0.53 and p=0.79, respectively). Conclusion. The −137 (G/C) IL-18 promoter polymorphism is not a susceptibility factor for IBD in a German cohort. |
DOI: | doi:10.1080/00365520510023738 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1080/00365520510023738 |
| Volltext: https://www.tandfonline.com/doi/full/10.1080/00365520510023738 |
| DOI: https://doi.org/10.1080/00365520510023738 |
Datenträger: | Online-Ressource |
Sprache: | eng |
Sach-SW: | Crohn's disease |
| inflammatory bowel disease |
| interleukin-18 |
| polymorphism |
| ulcerative colitis |
K10plus-PPN: | 1801180431 |
Verknüpfungen: | → Zeitschrift |
-137 (G/C) IL-18 promoter polymorphism in patients with inflammatory bowel disease / Haas, Stephan [VerfasserIn]; 2005 (Online-Ressource)