| Online-Ressource |
Verfasst von: | Davis, Stephen [VerfasserIn]  |
| Broderick, J. [VerfasserIn]  |
| Hennerici, Michael G. [VerfasserIn]  |
| Brun, N. C. [VerfasserIn]  |
| Diringer, M. N. [VerfasserIn]  |
| Mayer, S. A. [VerfasserIn]  |
| Begtrup, K. [VerfasserIn]  |
| Steiner, T. [VerfasserIn]  |
Titel: | Hematoma growth is a determinant of mortality and poor outcome after intracerebral hemorrhage |
Verf.angabe: | S.M. Davis, J. Broderick, M. Hennerici, N.C. Brun, M.N. Diringer, S.A. Mayer, K. Begtrup, and T. Steiner, for the Recombinant Activated Factor VII Intracerebral Hemorrhage Trial Investigators |
E-Jahr: | 2006 |
Jahr: | April 24, 2006 |
Umfang: | 7 S. |
Fussnoten: | Gesehen am 09.05.2022 |
Titel Quelle: | Enthalten in: Neurology |
Ort Quelle: | Philadelphia, Pa. : Wolters Kluwer, 1951 |
Jahr Quelle: | 2006 |
Band/Heft Quelle: | 66(2006), 8, Seite 1175-1181 |
ISSN Quelle: | 1526-632X |
Abstract: | BACKGROUND: Although volume of intracerebral hemorrhage (ICH) is a predictor of mortality, it is unknown whether subsequent hematoma growth further increases the risk of death or poor functional outcome. - METHODS: To determine if hematoma growth independently predicts poor outcome, the authors performed an individual meta-analysis of patients with spontaneous ICH who had CT within 3 hours of onset and 24-hour follow-up. Placebo patients were pooled from three trials investigating dosing, safety, and efficacy of rFVIIa (n = 115), and 103 patients from the Cincinnati study (total 218). Other baseline factors included age, gender, blood glucose, blood pressure, Glasgow Coma Score (GCS), intraventricular hemorrhage (IVH), and location. - RESULTS: Overall, 72.9% of patients exhibited some degree of hematoma growth. Percentage hematoma growth (hazard ratio [HR] 1.05 per 10% increase [95% CI: 1.03, 1.08; p < 0.0001]), initial ICH volume (HR 1.01 per mL [95% CI: 1.00, 1.02; p = 0.003]), GCS (HR 0.88 [95% CI: 0.81, 0.96; p = 0.003]), and IVH (HR 2.23 [95% CI: 1.25, 3.98; p = 0.007]) were all associated with increased mortality. Percentage growth (cumulative OR 0.84 [95% CI: 0.75, 0.92; p < 0.0001]), initial ICH volume (cumulative OR 0.94 [95% CI: 0.91, 0.97; p < 0.0001]), GCS (cumulative OR 1.46 [95% CI: 1.21, 1.82; p < 0.0001]), and age (cumulative OR 0.95 [95% CI: 0.92, 0.98; p = 0.0009]) predicted outcome modified Rankin Scale. Gender, location, blood glucose, and blood pressure did not predict outcomes. - CONCLUSIONS: Hematoma growth is an independent determinant of both mortality and functional outcome after intracerebral hemorrhage. Attenuation of growth is an important therapeutic strategy. |
DOI: | doi:10.1212/01.wnl.0000208408.98482.99 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1212/01.wnl.0000208408.98482.99 |
| DOI: https://doi.org/10.1212/01.wnl.0000208408.98482.99 |
Datenträger: | Online-Ressource |
Sprache: | eng |
Sach-SW: | Aged |
| Cerebral Hemorrhage |
| Factor VII |
| Factor VIIa |
| Female |
| Hematoma, Subdural |
| Humans |
| Male |
| Prognosis |
| Recombinant Proteins |
| Risk Factors |
| Tomography, X-Ray Computed |
K10plus-PPN: | 1801195072 |
Verknüpfungen: | → Zeitschrift |
Hematoma growth is a determinant of mortality and poor outcome after intracerebral hemorrhage / Davis, Stephen [VerfasserIn]; April 24, 2006 (Online-Ressource)