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Status: Bibliographieeintrag

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Verfasst von:Basile, Anna Maria [VerfasserIn]   i
 Pantoni, Leonardo [VerfasserIn]   i
 Pracucci, Giovanni [VerfasserIn]   i
 Asplund, Kjell [VerfasserIn]   i
 Chabriat, Hugues [VerfasserIn]   i
 Erkinjuntti, Timo [VerfasserIn]   i
 Fazekas, Franz [VerfasserIn]   i
 Ferro, José M. [VerfasserIn]   i
 Hennerici, Michael G. [VerfasserIn]   i
 O'Brien, John [VerfasserIn]   i
 Scheltens, Philip [VerfasserIn]   i
 Visser, Marieke C. [VerfasserIn]   i
 Wahlund, Lars-Olof [VerfasserIn]   i
 Waldemar, Gunhild [VerfasserIn]   i
 Wallin, Anders [VerfasserIn]   i
 Inzitari, Domenico [VerfasserIn]   i
Titel:Age, hypertension, and lacunar stroke are the major determinants of the severity of age-related white matter changes
Titelzusatz:the LADIS (Leukoaraiosis and Disability in the Elderly) Study
Verf.angabe:Anna Maria Basile, Leonardo Pantoni, Giovanni Pracucci, Kjell Asplund, Hugues Chabriat, Timo Erkinjuntti, Franz Fazekas, José M. Ferro, Michael Hennerici, John O'Brien, Philip Scheltens, Marieke C. Visser, Lars-Olof Wahlund, Gunhild Waldemar, Anders Wallin, Domenico Inzitari on behalf of the LADIS Study Group
E-Jahr:2006
Jahr:February 14, 2006
Umfang:8 S.
Fussnoten:Gesehen am 09.05.2022
Titel Quelle:Enthalten in: Cerebrovascular diseases
Ort Quelle:Basel : Karger, 1991
Jahr Quelle:2006
Band/Heft Quelle:21(2006), 5-6, Seite 315-322
ISSN Quelle:1421-9786
Abstract:BACKGROUND: Age-related white matter changes (ARWMC), seen on neuroimaging with high frequency in older people, are thought to be consequent to the effect of vascular risk factors and vascular diseases including hypertension and stroke. Among the proofs conventionally required for a factor to be considered a risk factor for a definite pathology, there is the demonstration of a trend in risk exposure related to disease severity. We sought whether such a trend existed in the association of vascular risk factors or comorbidities with the severity of ARWMC aiming particularly at further elucidating the relative roles of hypertension and stroke in this regard. - METHODS: The LADIS (Leukoaraiosis and Disability) Study is evaluating the role of ARWMC as an independent determinant of the transition to disability in the elderly. Six hundred and thirty-nine nondisabled subjects (mean age 74.1+/-5.0, M/F: 288/351) with ARWMC of different severity grades on MRI (mild, moderate, or severe according to the Fazekas scale) were assessed at baseline for demographics, vascular risk factors, and comorbidities, and are being followed up for 3 years. - RESULTS: Age, frequency of hypertension and history of stroke increased along with increasing ARWMC severity independently of other factors. For hypertension, however, this occurred only in subjects without a stroke history, while for stroke history, it mainly depended on lacunar stroke. The amount of cigarettes smoked and the interaction between hypercholesterolemia and smoking predicted only the most severe ARWMC grade. - CONCLUSIONS: The LADIS Study confirms that age, hypertension and lacunar strokes are the major determinants of ARWMC. Smoking and hypercholesterolemia provide additional risk.
DOI:doi:10.1159/000091536
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1159/000091536
 DOI: https://doi.org/10.1159/000091536
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Age Factors
 Aged
 Brain Infarction
 Databases, Factual
 Disability Evaluation
 Female
 Humans
 Hypertension
 Leukoaraiosis
 Magnetic Resonance Imaging
 Male
 Risk Factors
 Severity of Illness Index
K10plus-PPN:1801197407
Verknüpfungen:→ Zeitschrift

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