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| Verfasst von: | Maywald, Ole [VerfasserIn]  |
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| | Pfirrmann, M. [VerfasserIn] |
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| | Berger, Ute [VerfasserIn] |
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| | Breitscheidel, L. [VerfasserIn] |
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| | Gratwohl, A. [VerfasserIn] |
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| | Kolb, H.-J. [VerfasserIn] |
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| | Beelen, D. W. [VerfasserIn] |
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| | Tobler, A. [VerfasserIn] |
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| | Metzgeroth, Georgia [VerfasserIn] |
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| | Gnad, S. U. [VerfasserIn] |
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| | Hochhaus, Andreas [VerfasserIn] |
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| | Hasford, J. [VerfasserIn] |
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| | Hehlmann, Rüdiger [VerfasserIn] |
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| | Reiter, Andreas [VerfasserIn] |
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| Titel: | Cytogenetic response to prior treatment with interferon-α is predictive for survival after allogeneic hematopoietic stem cell transplantation in chronic myeloid leukemia |
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| Verf.angabe: | O. Maywald, M. Pfirrmann, U. Berger, L. Breitscheidel, A. Gratwohl, H.-J. Kolb, D.W. Beelen, A. Tobler, G. Metzgeroth, S.U. Gnad, A. Hochhaus, J. Hasford, R. Hehlmann, A. Reiter, for the German CML Study Group and the Swiss group of Clinical Cancer Research (SAKK) |
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| E-Jahr: | 2006 |
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| Jahr: | 02 February 2006 |
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| Umfang: | 8 S. |
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| Fussnoten: | Gesehen am 10.05.2022 |
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| Titel Quelle: | Enthalten in: Leukemia |
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| Ort Quelle: | London : Springer Nature, 1997 |
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| Jahr Quelle: | 2006 |
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| Band/Heft Quelle: | 20(2006), 3, Seite 477-484 |
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| ISSN Quelle: | 1476-5551 |
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| Abstract: | We investigated the impact of a cytogenetic response (CyR) to IFN prior to and at the time of allogeneic hematopoietic stem cell transplantation (HSCT) on transplant-related mortality (TRM), relapse rate and survival probability after HSCT in 162 transplanted patients with chronic myeloid leukemia. One-hundred-one patients (62.3%) achieved a CyR prior to HSCT. Survival probabilities were higher in patients, who achieved any CyR prior to HSCT than in patients without CyR (63.6 vs 49.2%: P=0.019). Survival probabilities in patients, who achieved a major CyR were better than in patients with minimal and minor CyR or in patients with no CyR (69.4 vs 58.8% vs 49.2%: P=0.040). TRM and survival of chronic phase patients without CyR at the time of HSCT were similar to that of patients transplanted in advanced phase. Both groups combined had an outcome inferior to patients with at least minimal CyR (TRM, Gray test: P=0.016, survival, log-rank test: P=0.002). Univariate and multivariate analyses identified CyR prior to or at HSCT as a strong and independently favorable prognostic factor. We therefore conclude that allogeneic HSCT in CyR should be investigated prospectively as an alternative treatment option in defined patient groups. |
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| DOI: | doi:10.1038/sj.leu.2404100 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1038/sj.leu.2404100 |
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| | Volltext: https://www.nature.com/articles/2404100 |
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| | DOI: https://doi.org/10.1038/sj.leu.2404100 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Cancer Research |
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| | general |
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| | Hematology |
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| | Intensive / Critical Care Medicine |
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| | Internal Medicine |
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| | Medicine/Public Health |
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| | Oncology |
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| K10plus-PPN: | 1801287228 |
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| Verknüpfungen: | → Zeitschrift |
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Cytogenetic response to prior treatment with interferon-α is predictive for survival after allogeneic hematopoietic stem cell transplantation in chronic myeloid leukemia / Maywald, Ole [VerfasserIn]; 02 February 2006 (Online-Ressource)
