| |  Online-Ressource |
|---|
| Verfasst von: | Reiter, Andreas [VerfasserIn]  |
|---|
| | Walz, Christoph [VerfasserIn] |
|---|
| | Watmore, Ann [VerfasserIn] |
|---|
| | Schoch, Claudia [VerfasserIn] |
|---|
| | Blau, Ilona [VerfasserIn] |
|---|
| | Schlegelberger, Brigitte [VerfasserIn] |
|---|
| | Berger, Ute [VerfasserIn] |
|---|
| | Telford, Nick [VerfasserIn] |
|---|
| | Aruliah, Shilani [VerfasserIn] |
|---|
| | Yin, John A. [VerfasserIn] |
|---|
| | Vanstraelen, Danny [VerfasserIn] |
|---|
| | Barker, Helen F. [VerfasserIn] |
|---|
| | Taylor, Peter C. [VerfasserIn] |
|---|
| | O'Driscoll, Aisling [VerfasserIn] |
|---|
| | Benedetti, Fabio [VerfasserIn] |
|---|
| | Rudolph, Cornelia [VerfasserIn] |
|---|
| | Kolb, Hans-Jochem [VerfasserIn] |
|---|
| | Hochhaus, Andreas [VerfasserIn] |
|---|
| | Hehlmann, Rüdiger [VerfasserIn] |
|---|
| | Chase, Andrew [VerfasserIn] |
|---|
| | Cross, Nicholas C.P. [VerfasserIn] |
|---|
| Titel: | The t(8;9)(p22;p24) is a recurrent abnormality in chronic and acute leukemia that fuses PCM1 to JAK2 |
|---|
| Verf.angabe: | Andreas Reiter, Christoph Walz, Ann Watmore, Claudia Schoch, Ilona Blau, Brigitte Schlegelberger, Ute Berger, Nick Telford, Shilani Aruliah, John A. Yin, Danny Vanstraelen, Helen F. Barker, Peter C. Taylor, Aisling O'Driscoll, Fabio Benedetti, Cornelia Rudolph, Hans-Jochem Kolb, Andreas Hochhaus, Rüdiger Hehlmann, Andrew Chase, and Nicholas C.P. Cross |
|---|
| E-Jahr: | 2005 |
|---|
| Jahr: | April 1, 2005 |
|---|
| Umfang: | 6 S. |
|---|
| Fussnoten: | Gesehen am 11.05.2022 |
|---|
| Titel Quelle: | Enthalten in: Cancer research |
|---|
| Ort Quelle: | Philadelphia, Pa. : AACR, 1916 |
|---|
| Jahr Quelle: | 2005 |
|---|
| Band/Heft Quelle: | 65(2005), 7, Seite 2662-2667 |
|---|
| ISSN Quelle: | 1538-7445 |
|---|
| Abstract: | We have identified a t(8;9)(p21-23;p23-24) in seven male patients (mean age 50, range 32-74) with diverse hematologic malignancies and clinical outcomes: atypical chronic myeloid leukemia/chronic eosinophilic leukemia (n = 5), secondary acute myeloid leukemia (n = 1), and pre-B-cell acute lymphoblastic leukemia (n = 1). Initial fluorescence in situ hybridization studies of one patient indicated that the nonreceptor tyrosine kinase Janus-activated kinase 2 (JAK2) at 9p24 was disrupted. Rapid amplification of cDNA ends-PCR identified the 8p22 partner gene as human autoantigen pericentriolar material (PCM1), a gene encoding a large centrosomal protein with multiple coiled-coil domains. Reverse transcription-PCR and fluorescence in situ hybridization confirmed the fusion in this case and also identified PCM1-JAK2 in the six other t(8;9) patients. The breakpoints were variable in both genes, but in all cases the chimeric mRNA is predicted to encode a protein that retains several of the predicted coiled-coil domains from PCM1 and the entire tyrosine kinase domain of JAK2. Reciprocal JAK2-PCM1 mRNA was not detected in any patient. We conclude that human autoantigen pericentriolar material (PCM1)-JAK2 is a novel, recurrent fusion gene in hematologic malignancies. Patients with PCM1-JAK2 disease are attractive candidates for targeted signal transduction therapy. |
|---|
| DOI: | doi:10.1158/0008-5472.CAN-04-4263 |
|---|
| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1158/0008-5472.CAN-04-4263 |
|---|
| | DOI: https://doi.org/10.1158/0008-5472.CAN-04-4263 |
|---|
| Datenträger: | Online-Ressource |
|---|
| Sprache: | eng |
|---|
| K10plus-PPN: | 1801376921 |
|---|
| Verknüpfungen: | → Zeitschrift |
|---|
¬The¬ t(8;9)(p22;p24) is a recurrent abnormality in chronic and acute leukemia that fuses PCM1 to JAK2 / Reiter, Andreas [VerfasserIn]; April 1, 2005 (Online-Ressource)
