| |  Online-Ressource |
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| Verfasst von: | Sauter, Manuela [VerfasserIn]  |
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| | Sauter, Reinhard J. [VerfasserIn] |
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| | Nording, Henry [VerfasserIn] |
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| | Lin, Chaolan [VerfasserIn] |
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| | Olbrich, Marcus [VerfasserIn] |
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| | Autenrieth, Stella [VerfasserIn] |
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| | Gleißner, Christian A. [VerfasserIn] |
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| | Thunemann, Martin [VerfasserIn] |
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| | Otero, Nadia [VerfasserIn] |
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| | Lutgens, Esther [VerfasserIn] |
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| | Aherrahrou, Zouhair [VerfasserIn] |
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| | Wolf, Dennis [VerfasserIn] |
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| | Zender, Lars [VerfasserIn] |
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| | Meuth, Sven [VerfasserIn] |
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| | Feil, Robert [VerfasserIn] |
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| | Langer, Harald F. [VerfasserIn] |
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| Titel: | Apolipoprotein E derived from CD11c+ cells ameliorates atherosclerosis |
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| Verf.angabe: | Manuela Sauter, Reinhard J. Sauter, Henry Nording, Chaolan Lin, Marcus Olbrich, Stella Autenrieth, Christian Gleissner, Martin Thunemann, Nadia Otero, Esther Lutgens, Zouhair Aherrahrou, Dennis Wolf, Lars Zender, Sven Meuth, Robert Feil, and Harald F. Langer |
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| Jahr: | 2022 |
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| Umfang: | 20 S. |
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| Fussnoten: | Available online 25 December 2021 ; Im Titel ist das Pluszeichen "+" hochgestellt ; Gesehen am 11.05.2022 |
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| Titel Quelle: | Enthalten in: iScience |
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| Ort Quelle: | Amsterdam : Elsevier, 2018 |
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| Jahr Quelle: | 2022 |
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| Band/Heft Quelle: | 25(2022), 1 vom: Jan., Artikel-ID 103677, Seite 1-20 |
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| ISSN Quelle: | 2589-0042 |
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| Abstract: | Atherosclerosis is studied in models with dysfunctional lipid homeostasis—predominantly the ApoE−/− mouse. The role of antigen-presenting cells (APCs) for lipid homeostasis is not clear. Using a LacZ reporter mouse, we showed that CD11c+ cells were enriched in aortae of ApoE−/− mice. Systemic long-term depletion of CD11c+ cells in ApoE−/− mice resulted in significantly increased plaque formation associated with reduced serum ApoE levels. In CD11ccre+ApoEfl/fl and Albumincre+ApoEfl/fl mice, we could show that ≈70% of ApoE is liver-derived and ≈25% originates from CD11c+ cells associated with significantly increased atherosclerotic plaque burden in both strains. Exposure to acLDL promoted cholesterol efflux from CD11c+ cells and cell-specific deletion of ApoE resulted in increased inflammation reflected by increased IL-1β serum levels. Our results determined for the first time the level of ApoE originating from CD11c+ cells and demonstrated that CD11c+ cells ameliorate atherosclerosis by the secretion of ApoE. |
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| DOI: | doi:10.1016/j.isci.2021.103677 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1016/j.isci.2021.103677 |
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| | Volltext: https://www.sciencedirect.com/science/article/pii/S2589004221016473 |
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| | DOI: https://doi.org/10.1016/j.isci.2021.103677 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Biological sciences |
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| | Components of the immune system |
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| | Immune response |
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| | Molecular biology |
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| K10plus-PPN: | 1801381569 |
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| Verknüpfungen: | → Zeitschrift |
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Apolipoprotein E derived from CD11c+ cells ameliorates atherosclerosis / Sauter, Manuela [VerfasserIn]; 2022 (Online-Ressource)
