| |  Online-Ressource |
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| Verfasst von: | Berger, Ute [VerfasserIn]  |
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| | Maywald, Ole [VerfasserIn] |
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| | Pfirrmann, M. [VerfasserIn] |
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| | Lahaye, T. [VerfasserIn] |
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| | Hochhaus, Andreas [VerfasserIn] |
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| | Reiter, Andreas [VerfasserIn] |
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| | Hasford, J. [VerfasserIn] |
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| | Heimpel, H. [VerfasserIn] |
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| | Hossfeld, D. K. [VerfasserIn] |
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| | Kolb, H.-J. [VerfasserIn] |
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| | Löffler, H. [VerfasserIn] |
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| | Pralle, H. [VerfasserIn] |
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| | Queißer, Wolfgang [VerfasserIn] |
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| | Hehlmann, Rüdiger [VerfasserIn] |
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| Titel: | Gender aspects in chronic myeloid leukemia |
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| Titelzusatz: | long-term results from randomized studies |
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| Verf.angabe: | U. Berger, O. Maywald, M. Pfirrmann, T. Lahaye, A. Hochhaus, A. Reiter, J. Hasford, H. Heimpel, D.K. Hossfeld, H.-J. Kolb, H. Löffler, H. Pralle, W. Queisser, R. Hehlmann and the German CML-Study Group |
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| E-Jahr: | 2005 |
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| Jahr: | 14 April 2005 |
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| Umfang: | 6 S. |
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| Fussnoten: | Gesehen am 12.05.2022 |
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| Titel Quelle: | Enthalten in: Leukemia |
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| Ort Quelle: | London : Springer Nature, 1997 |
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| Jahr Quelle: | 2005 |
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| Band/Heft Quelle: | 19(2005), 6, Seite 984-989 |
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| ISSN Quelle: | 1476-5551 |
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| Abstract: | Gender-related aspects in chronic myeloid leukemia (CML) have not been studied well. We therefore analyzed 856 patients with Ph/BCR-ABL-positive CML from the German randomized CML-studies I (interferon α (IFN) vs hydroxyurea (HU) vs busulfan) and II (IFN+HU vs HU alone). The median observation time was 8.6 years. A total of 503 patients (59%) were male. Female patients were older (51 vs 46 years; P<0.0001), presented with lower hemoglobin (11.7 vs 12.5 g/dl; P<0.0001), higher platelet counts (459 vs 355 × 109/l; P<0.0001), smaller spleen size (3 vs 4 cm below costal margin; P=0.0097), a lower rate of additional cytogenetic aberrations (9 vs 15%; P=0.018) and a less favorable risk profile (P=0.036). The transplantation rate was 14% for female (n=48) and 22% for male patients (n=113). Median survival was longer in female patients (58 vs 49 months; P=0.035) mainly attributable to better survival in the low- and intermediate-risk groups and, independent from risk groups, in the HU group. These results were confirmed by matched-pair analyses based on German population data (n=496, 59 vs 45 months; P=0.0006). This is the first analysis of gender aspects in CML using randomized trials. It demonstrates the relevance of analyses of gender differences in CML and in malignant disease at large. |
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| DOI: | doi:10.1038/sj.leu.2403756 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1038/sj.leu.2403756 |
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| | Volltext: https://www.nature.com/articles/2403756 |
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| | DOI: https://doi.org/10.1038/sj.leu.2403756 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Cancer Research |
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| | general |
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| | Hematology |
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| | Intensive / Critical Care Medicine |
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| | Internal Medicine |
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| | Medicine/Public Health |
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| | Oncology |
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| K10plus-PPN: | 1801670552 |
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| Verknüpfungen: | → Zeitschrift |
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Gender aspects in chronic myeloid leukemia / Berger, Ute [VerfasserIn]; 14 April 2005 (Online-Ressource)
