Red and processed meat intake, polygenic risk score, and colorectal cancer risk

• Verfasst von: Chen, Xuechen [VerfasserIn]
• Verfasst von: Hoffmeister, Michael [VerfasserIn]
• Verfasst von: Brenner, Hermann [VerfasserIn]
• Titel: Red and processed meat intake, polygenic risk score, and colorectal cancer risk
• Verf.angabe: Xuechen Chen, Michael Hoffmeister and Hermann Brenner
• E-Jahr: 2022
• Jahr: 3 March 2022
• Umfang: 12 S.
• Fussnoten: Gesehen am 12.05.2022 ; This article belongs to the Section "Nutrigenetics and nutrigenomics"
• Titel Quelle: Enthalten in: Nutrients
• Ort Quelle: Basel : MDPI, 2009
• Jahr Quelle: 2022
• Band/Heft Quelle: 14(2022), 5, Artikel-ID 1077, Seite 1-12
• ISSN Quelle: 2072-6643
• DOI: doi:10.3390/nu14051077
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: colorectal cancer
• Sach-SW: genetic risk equivalent
• Sach-SW: polygenic risk score
• Sach-SW: red and processed meat
• K10plus-PPN: 1801696756

Abstract

High red and processed meat intake (RPMI) is an established risk factor for colorectal cancer (CRC). We aimed to assess the impact of RPMI on CRC risk according to and in comparison with genetically determined risk, which was quantified by a polygenic risk score (PRS). RPMI and potential confounders (ascertained by questionnaire) and a PRS (based on 140 CRC-related loci) were obtained from 5109 CRC cases and 4134 controls in a population-based case-control study. Associations of RPMI with CRC risk across PRS levels were assessed using logistic regression models and compared to effect estimates of PRS using “genetic risk equivalent” (GRE), a novel metric for effective risk communication. RPMI multiple times/week, 1 time/day, and >1 time/day was associated with 19% (95% CI 1% to 41%), 41% (18% to 70%), and 73% (30% to 132%) increased CRC risk, respectively, when compared to RPMI ≤ 1 time/week. Associations were independent of PRS levels (pinteraction = 0.97). The effect of RPMI > 1 time/day was equivalent to the effect of having 42 percentiles higher PRS level (GRE 42, 95% CI 20-65). RPMI increases CRC risk regardless of PRS levels. Avoiding RPMI can compensate for a substantial proportion of polygenic risk for CRC.