| |  Online-Ressource |
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| Verfasst von: | Müller, Martin Christian [VerfasserIn]  |
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| | Gattermann, N. [VerfasserIn] |
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| | Lahaye, T. [VerfasserIn] |
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| | Deininger, M. W. N. [VerfasserIn] |
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| | Berndt, A. [VerfasserIn] |
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| | Frühauf, Stefan [VerfasserIn] |
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| | Neubauer, A. [VerfasserIn] |
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| | Fischer, Thomas [VerfasserIn] |
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| | Hossfeld, D. K. [VerfasserIn] |
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| | Schneller, F. [VerfasserIn] |
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| | Krause, S. W. [VerfasserIn] |
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| | Nerl, C. [VerfasserIn] |
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| | Sayer, H. G. [VerfasserIn] |
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| | Ottmann, O. G. [VerfasserIn] |
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| | Waller, C. [VerfasserIn] |
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| | Aulitzky, W. [VerfasserIn] |
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| | Coutre, P. le [VerfasserIn] |
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| | Freund, M. [VerfasserIn] |
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| | Merx, Kirsten [VerfasserIn] |
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| | Paschka, Peter [VerfasserIn] |
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| | König, H. [VerfasserIn] |
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| | Kreil, Sebastian [VerfasserIn] |
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| | Berger, Ute [VerfasserIn] |
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| | Gschaidmeier, Harald [VerfasserIn] |
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| | Hehlmann, Rüdiger [VerfasserIn] |
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| | Hochhaus, Andreas [VerfasserIn] |
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| Titel: | Dynamics of BCR-ABL mRNA expression in first-line therapy of chronic myelogenous leukemia patients with imatinib or interferon α/ara-C |
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| Verf.angabe: | M. C. Müller, N. Gattermann, T. Lahaye, M. W. N. Deininger, A. Berndt, S. Fruehauf, A. Neubauer, T. Fischer, D. K. Hossfeld, F. Schneller, S. W. Krause, C. Nerl, H. G. Sayer, O. G. Ottmann, C. Waller, W. Aulitzky, P. le Coutre, M. Freund, K. Merx, P. Paschka, H. König, S. Kreil, U. Berger, H. Gschaidmeier, R. Hehlmann and A. Hochhaus |
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| E-Jahr: | 2003 |
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| Jahr: | 02 October 2003 |
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| Umfang: | 9 S. |
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| Fussnoten: | Gesehen am 13.05.2022 |
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| Titel Quelle: | Enthalten in: Leukemia |
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| Ort Quelle: | London : Springer Nature, 1997 |
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| Jahr Quelle: | 2003 |
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| Band/Heft Quelle: | 17(2003), 12, Seite 2392-2400 |
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| ISSN Quelle: | 1476-5551 |
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| Abstract: | We sought to determine dynamics of BCR-ABL mRNA expression levels in 139 patients with chronic myelogenous leukemia (CML) in early chronic phase, randomized to receive imatinib (n=69) or interferon (IFN)/Ara-C (n=70). The response was sequentially monitored by cytogenetics from bone marrow metaphases (n=803) and qualitative and quantitative RT-PCR from peripheral blood samples (n=1117). Complete cytogenetic response (CCR) was achieved in 60 (imatinib, 87%) vs 10 patients (IFN/Ara-C, 14%) after a median observation time of 24 months. Within the first year after CCR, best median ratio BCR-ABL/ABL was 0.087%, (imatinib, n=48) vs 0.27% (IFN/Ara-C, n=9, P=0.025). BCR-ABL was undetectable in 25 cases by real-time PCR, but in only four patients by nested PCR. Median best response in patients with relapse after CCR was 0.24% (n=3) as compared to 0.029% in patients with continuous remission (n=52, P=0.029). We conclude that (i) treatment with imatinib in newly diagnosed CML patients is associated with a rapid decrease of BCR-ABL transcript levels; (ii) nested PCR may reveal residual BCR-ABL transcripts in samples that are negative by real-time PCR; (iii) BCR-ABL transcript levels parallel cytogenetic response, and (iv) imatinib is superior to IFN/Ara-C in terms of the speed and degree of molecular responses, but residual disease is rarely eliminated. |
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| DOI: | doi:10.1038/sj.leu.2403157 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1038/sj.leu.2403157 |
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| | Volltext: https://www.nature.com/articles/2403157 |
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| | DOI: https://doi.org/10.1038/sj.leu.2403157 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Cancer Research |
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| | general |
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| | Hematology |
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| | Intensive / Critical Care Medicine |
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| | Internal Medicine |
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| | Medicine/Public Health |
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| | Oncology |
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| K10plus-PPN: | 1801712336 |
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| Verknüpfungen: | → Zeitschrift |
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Dynamics of BCR-ABL mRNA expression in first-line therapy of chronic myelogenous leukemia patients with imatinib or interferon α/ara-C / Müller, Martin Christian [VerfasserIn]; 02 October 2003 (Online-Ressource)
