| |  Online-Ressource |
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| Verfasst von: | Büsche, Guntram [VerfasserIn]  |
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| | Hehlmann, Rüdiger [VerfasserIn] |
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| | Hecker, H. [VerfasserIn] |
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| | Heimpel, H. [VerfasserIn] |
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| | Heinze, B. [VerfasserIn] |
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| | Schmeil, A. [VerfasserIn] |
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| | Pfirrmann, M. [VerfasserIn] |
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| | Gomez, G. [VerfasserIn] |
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| | Tobler, A. [VerfasserIn] |
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| | Herrmann, H. [VerfasserIn] |
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| | Kappler, M. [VerfasserIn] |
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| | Hasford, J. [VerfasserIn] |
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| | Buhr, T. [VerfasserIn] |
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| | Kreipe, H.-H. [VerfasserIn] |
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| | Georgii, A. [VerfasserIn] |
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| Titel: | Marrow fibrosis, indicator of therapy failure in chronic myeloid leukemia - prospective long-term results from a randomized-controlled trial |
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| Verf.angabe: | G. Buesche, R. Hehlmann, H. Hecker, H. Heimpel, B. Heinze, A. Schmeil, M. Pfirrmann, G. Gomez, A. Tobler, H. Herrmann, M. Kappler, J. Hasford, T. Buhr, H.-H. Kreipe, A. Georgii and the German CML Study Group |
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| E-Jahr: | 2003 |
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| Jahr: | 16 October 2003 |
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| Umfang: | 10 S. |
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| Fussnoten: | Gesehen am 13.05.2022 |
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| Titel Quelle: | Enthalten in: Leukemia |
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| Ort Quelle: | London : Springer Nature, 1997 |
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| Jahr Quelle: | 2003 |
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| Band/Heft Quelle: | 17(2003), 12, Seite 2444-2453 |
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| ISSN Quelle: | 1476-5551 |
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| Abstract: | Marrow fibrosis (MF) has rarely been considered in therapy studies on chronic myeloid leukemia (CML), and there is a lack of long-term observations on the basis of sequential bone marrow biopsies (BMBs) taken prospectively during the course of disease. A total of 848 BMBs from 400 patients with Ph+ CML recruited in the German randomized CML study I were examined for MF before and during therapy. In total, 110 patients had been randomized to receive interferon (IFN)-α, and 290 to receive chemotherapy (hydroxyurea (HU): 154, busulfan: 136). During IFN-α and HU medication, MF was reduced or did not increase for about 2 years. Evolving or progressive MF was an independent and early predictor of therapy failure about 2 years earlier than indicated by changes in the peripheral blood, spleen size, marrow blast count and cytogenetics (P<0.00005), resulting in a significant shortening of the survival times of patients independent of the type of therapy applied including allografting (multivariate analyses; P<0.00005). The analyzed long-term observations strongly indicate that MF is an independent poor prognostic complication of CML, allowing an early prediction of therapy failure. Consideration of the fiber content in marrow may therefore significantly improve the prediction of therapy efficacy and outcome of disease. |
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| DOI: | doi:10.1038/sj.leu.2403172 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1038/sj.leu.2403172 |
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| | Volltext: https://www.nature.com/articles/2403172 |
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| | DOI: https://doi.org/10.1038/sj.leu.2403172 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Bibliogr. Hinweis: | Erscheint auch als : Druck-Ausgabe: Marrow fibrosis, indicator of therapy failure in chronic myeloid leukemia - prospective long-term results from a randomized-controlled trial. - 2003 |
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| Sach-SW: | Cancer Research |
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| | general |
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| | Hematology |
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| | Intensive / Critical Care Medicine |
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| | Internal Medicine |
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| | Medicine/Public Health |
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| | Oncology |
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| K10plus-PPN: | 1801718202 |
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| Verknüpfungen: | → Zeitschrift |
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Marrow fibrosis, indicator of therapy failure in chronic myeloid leukemia - prospective long-term results from a randomized-controlled trial / Büsche, Guntram [VerfasserIn]; 16 October 2003 (Online-Ressource)
