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| Verfasst von: | Schniewind, Iñaki [VerfasserIn]  |
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| | Hadiwikarta, Wahyu Wijaya [VerfasserIn] |
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| | Grajek, Julia [VerfasserIn] |
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| | Poleszczuk, Jan [VerfasserIn] |
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| | Richter, Susan [VerfasserIn] |
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| | Peitzsch, Mirko [VerfasserIn] |
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| | Müller, Johannes [VerfasserIn] |
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| | Klusa, Daria [VerfasserIn] |
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| | Beyreuther, Elke [VerfasserIn] |
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| | Löck, Steffen [VerfasserIn] |
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| | Lühr, Armin [VerfasserIn] |
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| | Frosch, Susanne [VerfasserIn] |
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| | Groeben, Christer [VerfasserIn] |
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| | Sommer, Ulrich [VerfasserIn] |
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| | Krause, Mechthild [VerfasserIn] |
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| | Dubrovska, Anna [VerfasserIn] |
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| | Neubeck, Cläre von [VerfasserIn] |
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| | Kurth, Ina [VerfasserIn] |
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| | Peitzsch, Claudia [VerfasserIn] |
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| Titel: | Cellular plasticity upon proton irradiation determines tumor cell radiosensitivity |
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| Verf.angabe: | Iñaki Schniewind, Wahyu Wijaya Hadiwikarta, Julia Grajek, Jan Poleszczuk, Susan Richter, Mirko Peitzsch, Johannes Müller, Daria Klusa, Elke Beyreuther, Steffen Löck, Armin Lühr, Susanne Frosch, Christer Groeben, Ulrich Sommer, Mechthild Krause, Anna Dubrovska, Cläre von Neubeck, Ina Kurth, and Claudia Peitzsch |
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| E-Jahr: | 2022 |
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| Jahr: | February 22, 2022 |
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| Umfang: | 22 S. |
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| Fussnoten: | Gesehen am 13.05.2022 |
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| Titel Quelle: | Enthalten in: Cell reports |
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| Ort Quelle: | Maryland Heights, MO : Cell Press, 2012 |
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| Jahr Quelle: | 2022 |
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| Band/Heft Quelle: | 38(2022), 8, Artikel-ID 110422, Seite 1-22 |
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| ISSN Quelle: | 2211-1247 |
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| Abstract: | Proton radiotherapy has been implemented into the standard-of-care for cancer patients within recent years. However, experimental studies investigating cellular and molecular mechanisms are lacking, and prognostic biomarkers are needed. Cancer stem cell (CSC)-related biomarkers, such as aldehyde dehydrogenase (ALDH), are known to influence cellular radiosensitivity through inactivation of reactive oxygen species, DNA damage repair, and cell death. In a previous study, we found that ionizing radiation itself enriches for ALDH-positive CSCs. In this study, we analyze CSC marker dynamics in prostate cancer, head and neck cancer, and glioblastoma cells upon proton beam irradiation. We find that proton irradiation has a higher potential to target CSCs through induction of complex DNA damages, lower rates of cellular senescence, and minor alteration in histone methylation pattern compared with conventional photon irradiation. Mathematical modeling indicates differences in plasticity rates among ALDH-positive CSCs and ALDH-negative cancer cells between the two irradiation types. |
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| DOI: | doi:10.1016/j.celrep.2022.110422 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1016/j.celrep.2022.110422 |
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| | Volltext: https://www.sciencedirect.com/science/article/pii/S2211124722001462 |
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| | DOI: https://doi.org/10.1016/j.celrep.2022.110422 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | cancer stem cells |
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| | cellular plasticity |
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| | epigenetics |
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| | glioblastoma |
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| | head and neck squamous cell carcinomas |
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| | prostate cancer |
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| | proton irradiation |
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| | radiobiology |
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| K10plus-PPN: | 1801720622 |
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| Verknüpfungen: | → Zeitschrift |
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Cellular plasticity upon proton irradiation determines tumor cell radiosensitivity / Schniewind, Iñaki [VerfasserIn]; February 22, 2022 (Online-Ressource)
