| Online-Ressource |
Verfasst von: | Hofheinz, Ralf-Dieter [VerfasserIn] ![i](/opacicon/information2.png) |
| Hartung, Gernot [VerfasserIn] ![i](/opacicon/information2.png) |
| Samel, Stefan [VerfasserIn] ![i](/opacicon/information2.png) |
| Emig, Michael [VerfasserIn] ![i](/opacicon/information2.png) |
| Pilz, Lothar R. [VerfasserIn] ![i](/opacicon/information2.png) |
| Willeke, Frank [VerfasserIn] ![i](/opacicon/information2.png) |
| Hochhaus, Andreas [VerfasserIn] ![i](/opacicon/information2.png) |
| Hehlmann, Rüdiger [VerfasserIn] ![i](/opacicon/information2.png) |
| Queißer, Wolfgang [VerfasserIn] ![i](/opacicon/information2.png) |
Titel: | Adding weekly irinotecan to high-dose 5-fluorouracil and folinic acid (HD-5-FU/FA) after failure for first-line HD-5-FU/FA in advanced colorectal cancer - a phase II study |
Verf.angabe: | Ralf Hofheinz, Gernot Hartung, Stefan Samel, Michael Emig, Lothar Pilz, Frank Willeke, Andreas Hochhaus, Rüdiger Hehlmann and Wolfgang Queisser |
E-Jahr: | 2002 |
Jahr: | November 2002 |
Umfang: | 6 S. |
Fussnoten: | Gesehen am 16.05.2022 |
Titel Quelle: | Enthalten in: Anti-cancer drugs |
Ort Quelle: | Hagerstown, Md. : Lippincott Williams & Wilkins, 1990 |
Jahr Quelle: | 2002 |
Band/Heft Quelle: | 13(2002), 10, Seite 999-1004 |
ISSN Quelle: | 1473-5741 |
Abstract: | Irinotecan (CPT-11) has been shown to prolong survival and improve quality of life in comparison to best supportive care in colorectal cancer patients with pretreatment of bolus 5-fluorouracil (5-FU). After first-line 24-h high-dose (HD) 5-FU/folinic acid (FA) an objective response rate of 11% with 3-weekly CPT-11 350 mg/m2 was reported. In the present study we investigated weekly CPT-11 in combination with 24-h HD-5-FU/FA as second-line treatment after prior exposure to 24-h HD-5-FU. Synergy between 5-FU and CPT-11 is the rationale to combine both substances for second-line therapy in order to overcome resistance to 5-FU. Thirty-five patients were recruited in a single institution to receive 6 × weekly CPT-11 80 mg/m2, FA 200 mg/m2 and 24-h HD-5-FU 2000 mg/m2. Treatment was repeated on day 57. Patient characteristics: M/F=20/15, median WHO performance status 1, range (0-2). Thirty-four patients were evaluable for response: partial response 17% and no change 40%. Median time to progression and overall survival were 3.3 and 8.4 months, respectively. All patients were evaluable for toxicity analysis (National Cancer Institute Common Toxicity Criteria grade 3): leukocytopenia 3%, diarrhea 12% and vomiting/nausea 6%. Of the assigned doses, a median 100% of 5-FU and 92% of CPT-11 were administered during the first cycle of chemotherapy. We conclude that weekly CPT-11 and HD-5-FU/FA is an active and safe combination chemotherapy resulting in response rates in the upper range of other CPT-11-based second-line regimen. The toxicity profile in our series compared to 3-weekly CPT-11 seems favorable. |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://journals.lww.com/anti-cancerdrugs/Fulltext/2002/11000/Adding_weekly_irinotecan_to_high_dose.3.aspx |
Datenträger: | Online-Ressource |
Sprache: | eng |
K10plus-PPN: | 1801847983 |
Verknüpfungen: | → Zeitschrift |
Adding weekly irinotecan to high-dose 5-fluorouracil and folinic acid (HD-5-FU/FA) after failure for first-line HD-5-FU/FA in advanced colorectal cancer - a phase II study / Hofheinz, Ralf-Dieter [VerfasserIn]; November 2002 (Online-Ressource)