Interdependence of angiogenesis and arteriogenesis in development and disease

• Verfasst von: Le Noble, Ferdinand [VerfasserIn]
• Verfasst von: Kupatt, Christian [VerfasserIn]
• Titel: Interdependence of angiogenesis and arteriogenesis in development and disease
• Verf.angabe: Ferdinand le Noble and Christian Kupatt
• E-Jahr: 2022
• Jahr: 31 March 2022
• Umfang: 13 S.
• Fussnoten: Gesehen am 17.05.2022
• Titel Quelle: Enthalten in: International journal of molecular sciences
• Ort Quelle: Basel : Molecular Diversity Preservation International, 2000
• Jahr Quelle: 2022
• Band/Heft Quelle: 23(2022), 7, Artikel-ID 3879, Seite 1-13
• ISSN Quelle: 1422-0067
• ISSN Quelle: 1661-6596
• DOI: doi:10.3390/ijms23073879
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: AAV
• Sach-SW: angiogenesis
• Sach-SW: arteriogenesis
• Sach-SW: blood flow
• Sach-SW: endothelial cell shape
• Sach-SW: MRTF-A
• Sach-SW: sFlt1
• Sach-SW: shear stress
• Sach-SW: Trio
• K10plus-PPN: 1802116885

Abstract

The structure of arterial networks is optimized to allow efficient flow delivery to metabolically active tissues. Optimization of flow delivery is a continuous process involving synchronization of the structure and function of the microcirculation with the upstream arterial network. Risk factors for ischemic cardiovascular diseases, such as diabetes mellitus and hyperlipidemia, adversely affect endothelial function, induce capillary regression, and disrupt the micro- to macrocirculation cross-talk. We provide evidence showing that this loss of synchronization reduces arterial collateral network recruitment upon arterial stenosis, and the long-term clinical outcome of current revascularization strategies in these patient cohorts. We describe mechanisms and signals contributing to synchronized growth of micro- and macrocirculation in development and upon ischemic challenges in the adult organism and identify potential therapeutic targets. We conclude that a long-term successful revascularization strategy should aim at both removing obstructions in the proximal part of the arterial tree and restoring “bottom-up” vascular communication.