| |  Online-Ressource |
|---|
| Verfasst von: | Thorn, Graeme J. [VerfasserIn]  |
|---|
| | Clarkson, Christopher T. [VerfasserIn] |
|---|
| | Rademacher, Anne [VerfasserIn] |
|---|
| | Mamayusupova, Hulkar [VerfasserIn] |
|---|
| | Schotta, Gunnar [VerfasserIn] |
|---|
| | Rippe, Karsten [VerfasserIn] |
|---|
| | Teif, Vladimir B. [VerfasserIn] |
|---|
| Titel: | DNA sequence-dependent formation of heterochromatin nanodomains |
|---|
| Verf.angabe: | Graeme J. Thorn, Christopher T. Clarkson, Anne Rademacher, Hulkar Mamayusupova, Gunnar Schotta, Karsten Rippe & Vladimir B. Teif |
|---|
| E-Jahr: | 2022 |
|---|
| Jahr: | 06 April 2022 |
|---|
| Umfang: | 13 S. |
|---|
| Fussnoten: | Gesehen am 17.05.2022 |
|---|
| Titel Quelle: | Enthalten in: Nature Communications |
|---|
| Ort Quelle: | [London] : Nature Publishing Group UK, 2010 |
|---|
| Jahr Quelle: | 2022 |
|---|
| Band/Heft Quelle: | 13(2022), Artikel-ID 1861, Seite 1-13 |
|---|
| ISSN Quelle: | 2041-1723 |
|---|
| Abstract: | The mammalian epigenome contains thousands of heterochromatin nanodomains (HNDs) marked by di- and trimethylation of histone H3 at lysine 9 (H3K9me2/3), which have a typical size of 3-10 nucleosomes. However, what governs HND location and extension is only partly understood. Here, we address this issue by introducing the chromatin hierarchical lattice framework (ChromHL) that predicts chromatin state patterns with single-nucleotide resolution. ChromHL is applied to analyse four HND types in mouse embryonic stem cells that are defined by histone methylases SUV39H1/2 or GLP, transcription factor ADNP or chromatin remodeller ATRX. We find that HND patterns can be computed from PAX3/9, ADNP and LINE1 sequence motifs as nucleation sites and boundaries that are determined by DNA sequence (e.g. CTCF binding sites), cooperative interactions between nucleosomes as well as nucleosome-HP1 interactions. Thus, ChromHL rationalizes how patterns of H3K9me2/3 are established and changed via the activity of protein factors in processes like cell differentiation. |
|---|
| DOI: | doi:10.1038/s41467-022-29360-y |
|---|
| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1038/s41467-022-29360-y |
|---|
| | Volltext: https://www.nature.com/articles/s41467-022-29360-y |
|---|
| | DOI: https://doi.org/10.1038/s41467-022-29360-y |
|---|
| Datenträger: | Online-Ressource |
|---|
| Sprache: | eng |
|---|
| Sach-SW: | Biological physics |
|---|
| | Epigenomics |
|---|
| | Gene regulation |
|---|
| | Gene silencing |
|---|
| | Histone post-translational modifications |
|---|
| K10plus-PPN: | 1802126856 |
|---|
| Verknüpfungen: | → Zeitschrift |
|---|
DNA sequence-dependent formation of heterochromatin nanodomains / Thorn, Graeme J. [VerfasserIn]; 06 April 2022 (Online-Ressource)
