NFκB inhibition to lift the mechano-competence of mesenchymal stromal cell-derived neocartilage toward articular chondrocyte levels

• Verfasst von: Lückgen, Janine [VerfasserIn]
• Verfasst von: Raqué, Elisabeth [VerfasserIn]
• Verfasst von: Reiner, Tobias [VerfasserIn]
• Verfasst von: Diederichs, Solvig [VerfasserIn]
• Verfasst von: Richter, Wiltrud [VerfasserIn]
• Titel: NFκB inhibition to lift the mechano-competence of mesenchymal stromal cell-derived neocartilage toward articular chondrocyte levels
• Verf.angabe: Janine Lückgen, Elisabeth Raqué, Tobias Reiner, Solvig Diederichs and Wiltrud Richter
• E-Jahr: 2022
• Jahr: 27 April 2022
• Umfang: 15 S.
• Fussnoten: Gesehen am 17.05.2022
• Titel Quelle: Enthalten in: Stem cell research & therapy
• Ort Quelle: London : BioMed Central, 2010
• Jahr Quelle: 2022
• Band/Heft Quelle: 13(2022), 1, Artikel-ID 168, Seite 1-15
• ISSN Quelle: 1757-6512
• DOI: doi:10.1186/s13287-022-02843-x
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: BMP
• Sach-SW: Chondrocytes
• Sach-SW: Extracellular matrix (ECM) synthesis
• Sach-SW: Mechanical loading
• Sach-SW: Mechano-competence
• Sach-SW: Mesenchymal stromal cells (MSC)
• Sach-SW: NFκB
• Sach-SW: Nitric oxide (NO)/iNOS
• Sach-SW: Prostaglandin E2 (PGE2)
• Sach-SW: Tissue engineering
• K10plus-PPN: 1802134190
• K10plus-PPN:
  Universitätsbibliothek
• Lokale URL UB: Zum Volltext

Abstract

Fully functional regeneration of skeletal defects by multipotent progenitor cells requires that differentiating cells gain the specific mechano-competence needed in the target tissue. Using cartilage neogenesis as an example, we asked whether proper phenotypic differentiation of mesenchymal stromal cells (MSC) into chondrocytes in vitro will install the adequate biological mechano-competence of native articular chondrocytes (AC).