Status: Bibliographieeintrag
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| Verfasst von: | Papakonstantinou, Georgios [VerfasserIn]  |
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| | Verbeke, Caroline Sophie [VerfasserIn] |
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| | Hastka, Jan [VerfasserIn] |
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| | Bohrer, Manfred H. [VerfasserIn] |
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| | Hehlmann, Rüdiger [VerfasserIn] |
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| Titel: | bcl-2 expression in non-Hodgkin's lymphomas is not associated with bcl-2 gene rearrangements |
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| Verf.angabe: | Georgios Papakonstantinou, Caroline Verbeke, Jan Hastka, Manfred Bohrer and Rüdiger Hehlmann |
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| Jahr: | 2001 |
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| Umfang: | 8 S. |
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| Fussnoten: | Elektronische Reproduktion der Druckausgabe ; Gesehen am 17.05.2022 |
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| Titel Quelle: | Enthalten in: British journal of haematology |
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| Ort Quelle: | Oxford [u.a.] : Wiley-Blackwell, 1955 |
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| Jahr Quelle: | 2001 |
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| Band/Heft Quelle: | 113(2001), 2, Seite 383-390 |
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| ISSN Quelle: | 1365-2141 |
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| Abstract: | Previous reports have associated bcl-2 gene rearrangements found in non-Hodgkin's lymphomas with an inappropriately elevated bcl-2 expression compared with the mature B-cell stage of development. This study investigates bcl-2 expression in non-Hodgkin's lymphomas (NHL) without bcl-2 gene rearrangements. Molecular analysis in 168 patients with NHL revealed 45 patients without bcl-2 gene rearrangements in which additional immunostaining for bcl-2 protein was possible. An unexpectedly high prevalence (39/45) of bcl-2 expression was found. The levels and patterns of bcl-2 expression were not specific for the histological type of NHL and were similar to those shown in comparable cases with bcl-2 gene rearrangements. In conclusion, bcl-2 expression is not specific for NHL bearing bcl-2 gene rearrangements. This finding implicates the existence of other deregulating control mechanisms of bcl-2 expression, more important than bcl-2 gene rearrangements. |
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| DOI: | doi:10.1046/j.1365-2141.2001.02727.x |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1046/j.1365-2141.2001.02727.x |
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| | Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1046/j.1365-2141.2001.02727.x |
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| | DOI: https://doi.org/10.1046/j.1365-2141.2001.02727.x |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | 18) translocation |
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| | bcl-2 |
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| | expression |
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| | non-Hodgkin lymphoma |
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| | rearrangement |
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| | t(14 |
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| K10plus-PPN: | 1802160620 |
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| Verknüpfungen: | → Zeitschrift |
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bcl-2 expression in non-Hodgkin's lymphomas is not associated with bcl-2 gene rearrangements / Papakonstantinou, Georgios [VerfasserIn]; 2001 (Online-Ressource)
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